公开(公告)号：US20090005576A1

公开(公告)日：2009-01-01

申请号：US11813809

申请日：2006-01-12

申请人： Koji Machiya ,  Kazuo Ike ,  Masaru Watanabe ,  Toshitaka Yoshino ,  Takumi Okamoto ,  Yasuhiro Morinaga ,  Shoji Mizobata

发明人： Koji Machiya ,  Kazuo Ike ,  Masaru Watanabe ,  Toshitaka Yoshino ,  Takumi Okamoto ,  Yasuhiro Morinaga ,  Shoji Mizobata

IPC分类号： C07D207/12

CPC分类号： C07D207/12

摘要： The present invention relates to an industrial synthetic method of an optically active cyclohexane ether compound (IIIa) or a salt thereof, which is useful as a pharmaceutical agent, and an intermediate useful for the production method of the present invention. The production method of the present invention is as shown below: wherein each symbol is as defined in the specification. According to the production method of the present invention, efficient and stable supply of an optically active cyclohexane ether compound (IIIa) in a high yield at a lower cost can be afforded. Therefore, an optically active cyclohexane ether compound (IIIa) extremely useful as a pharmaceutical agent can be provided by an industrially highly advantageous method.

摘要翻译： 本发明涉及可用作药剂的光学活性环己烷醚化合物（IIIa）或其盐的工业合成方法和可用于本发明的制备方法的中间体。 本发明的制造方法如下所示：其中各符号如说明书中所定义。 根据本发明的制造方法，能够以较低的成本高效稳定地供给光学活性的环己烷醚化合物（IIIa）。 因此，通过工业上非常有利的方法可以提供作为药剂非常有用的光学活性的环己烷醚化合物（IIIa）。