公开(公告)号：US20100143366A1

公开(公告)日：2010-06-10

申请号：US12707914

申请日：2010-02-18

申请人： Koji YOSHINAGA ,  Daisuke Kawasaki ,  Yutaka Emori

发明人： Koji YOSHINAGA ,  Daisuke Kawasaki ,  Yutaka Emori

IPC分类号： A61K31/5513 ,  A61P35/00 ,  A61K39/395

CPC分类号： A61K31/551 ,  A61K9/0053 ,  A61K31/513 ,  A61K31/7068 ,  A61K45/06 ,  C07D243/12 ,  A61K2300/00

摘要： To provide a pharmaceutical agent or an antitumor agent useful for the treatment and/or prevention of gastrointestinal cancer, leukemia, pituitary tumor, small cell lung cancer, thyroid cancer, and neuroastrocytoma. The antitumor agent containing, as an active ingredient, a 1,5-benzodiazepine derivative represented by the following formula (1): (wherein R1 represents a C1-6 alkyl group; R2 represents a phenyl group or a cyclohexyl group; and Y represents a single bond or a C1-4 alkylene group) or a pharmaceutically acceptable salt thereof.

摘要翻译： 提供可用于治疗和/或预防胃肠癌，白血病，垂体瘤，小细胞肺癌，甲状腺癌和神经细胞瘤的药剂或抗肿瘤剂。 作为活性成分含有下述式（1）表示的1,5-苯并二氮杂衍生物的抗肿瘤剂：其中，R1表示C1-6烷基，R2表示苯基或环己基，Y表示 单键或C1-4亚烷基）或其药学上可接受的盐。

公开(公告)号：US20100086553A1

公开(公告)日：2010-04-08

申请号：US12632182

申请日：2009-12-07

申请人： Koji YOSHINAGA ,  Daisuke Kawasaki ,  Yutaka Emori

发明人： Koji YOSHINAGA ,  Daisuke Kawasaki ,  Yutaka Emori

IPC分类号： A61K39/395 ,  A61K31/5517

CPC分类号： A61K31/551 ,  A61K9/0053 ,  A61K31/513 ,  A61K31/7068 ,  A61K45/06 ,  C07D243/12 ,  A61K2300/00

摘要： To provide a pharmaceutical agent or an antitumor agent useful for the treatment and/or prevention of gastrointestinal cancer, leukemia, pituitary tumor, small cell lung cancer, thyroid cancer, and neuroastrocytoma. The antitumor agent containing, as an active ingredient, a 1,5-benzodiazepine derivative represented by the following formula (1): (wherein R1 represents a C1-6 alkyl group; R2 represents a phenyl group or a cyclohexyl group; and Y represents a single bond or a C1-4 alkylene group) or a pharmaceutically acceptable salt thereof.