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公开(公告)号：US20150147765A1
公开(公告)日：2015-05-28
申请号：US14303939
申请日：2014-06-13
Applicant: Korea Basic Science Institute
Inventor： Yeong Hee Ahn , Jong Shin Yoo , Eun Sun Ji
IPC: G01N33/68
CPC classification number: G01N33/6818 , G01N33/57484
Abstract: The present invention relates to a method for diagnosing cancer using information on the aberrant glycosylation of a glycoprotein involved in cancer progress. More particularly, the present invention relates to a cancer diagnosis peptide marker which is screened by the steps of: separating a glycoprotein aberrantly glycosylated according to the occurrence and progress of cancer from the blood of a lung cancer patient by using lectin; and selecting a marker peptide produced by the hydrolysis of the glycoprotein isolated by lectin. The marker peptide can be effectively used as a cancer diagnosis marker and for the diagnosis of cancer.
Abstract translation: 本发明涉及使用涉及癌症进展的糖蛋白异常糖基化的信息来诊断癌症的方法。 更具体地，本发明涉及通过以下步骤进行筛选的癌症诊断肽标记：通过使用凝集素从根据癌症患者的血液的癌症的发生和进展而异糖基化的糖蛋白分离; 并选择由凝集素分离的糖蛋白的水解产生的标记肽。 标记肽可以有效地用作癌症诊断标记物和用于诊断癌症。
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公开(公告)号：US11215620B2
公开(公告)日：2022-01-04
申请号：US16296154
申请日：2019-03-07
Applicant: Korea Basic Science Institute
Inventor： Jin Young Kim , Gun Wook Park , Eun Sun Ji , Jong Shin Yoo
Abstract: The preset invention relates to a high resolution mass spectrometry based novel bioinformatics platform for the identification of glycation proteins and advanced glycation end-product. Particularly, the bioinformatics platform of the present invention facilitates an efficient and accurate investigation of quantitative changes of glycation proteins and advanced glycation end-products which are included in various types of samples but had not been informed yet, and uses a high resolution mass spectrometry, and thereby can be effectively used for the prediction or diagnosis of a disease including cancer by examining a disease marker in a sample.
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公开(公告)号：US20190285645A1
公开(公告)日：2019-09-19
申请号：US16296154
申请日：2019-03-07
Applicant: Korea Basic Science Institute
Inventor： Jin Young Kim , Gun Wook Park , Eun Sun Ji , Jong Shin Yoo
Abstract: The preset invention relates to a high resolution mass spectrometry based novel bioinformatics platform for the identification of glycation proteins and advanced glycation end-product. Particularly, the bioinformatics platform of the present invention facilitates an efficient and accurate investigation of quantitative changes of glycation proteins and advanced glycation end-products which are included in various types of samples but had not been informed yet, and uses a high resolution mass spectrometry, and thereby can be effectively used for the prediction or diagnosis of a disease including cancer by examining a disease marker in a sample.
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