公开(公告)号：US20190324015A1

公开(公告)日：2019-10-24

申请号：US16169020

申请日：2018-10-24

申请人： Korea Basic Science Institute

发明人： Gun H. Kim ,  Edmond C. Park ,  Seung I. Kim ,  Sang-Yeop Lee

IPC分类号： G01N33/50 ,  G01N33/53 ,  A61K31/7088 ,  C07K16/18 ,  G06F19/18 ,  G06F19/24 ,  G16H50/20

摘要： The present invention relates to a biomarker for diagnosis of overactive bladder (OAB) disease, and a method for screening a drug using the biomarker. The markers described in the present invention can effectively detect or diagnose the onset of OAB by distinguishing them from normal populations. In particular, OAB-specific protein markers released into urine enable simple and rapid OAB diagnosis in a non-invasive manner. In addition, by selecting an agent that changes, particularly normalizes the expression and activity of the markers selected in the present invention, more effective preventative or therapeutic agents of OAB disease can be screened.

公开(公告)号：US11531023B2

公开(公告)日：2022-12-20

申请号：US16169020

申请日：2018-10-24

申请人： Korea Basic Science Institute

发明人： Gun H. Kim ,  Edmond C. Park ,  Seung I. Kim ,  Sang-Yeop Lee

IPC分类号： C12Q1/68 ,  G01N33/50 ,  G01N33/53 ,  A61K31/7088 ,  C07K16/18 ,  G16H50/20 ,  G16B20/00 ,  G16B40/00

摘要： The present invention relates to a biomarker for diagnosis of overactive bladder (OAB) disease, and a method for screening a drug using the biomarker. The markers described in the present invention can effectively detect or diagnose the onset of OAB by distinguishing them from normal populations. In particular, OAB-specific protein markers released into urine enable simple and rapid OAB diagnosis in a non-invasive manner. In addition, by selecting an agent that changes, particularly normalizes the expression and activity of the markers selected in the present invention, more effective preventative or therapeutic agents of OAB disease can be screened.