公开(公告)号：US20190144602A1

公开(公告)日：2019-05-16

申请号：US16161522

申请日：2018-10-16

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hae Jung Son ,  Phillip Lee ,  Jeung-hyun Jeong ,  Gyoungsik Kim ,  Sungmin Park ,  Injeong Shin ,  Sung-yoon Joe ,  Ji Yeong Kim

IPC: C08G61/12

Abstract: Disclosed is a conjugated polymer for an organic solar cell. The proportion of units containing no alkyl thiophene moieties in the conjugated polymer can vary to make the conjugated polymer suitable for use as an electron-donating organic semiconductor material in a small-area or large-area organic solar cell. Therefore, the use of the conjugated polymer ensures high energy conversion efficiency of the organic solar cell.

公开(公告)号：US08946431B2

公开(公告)日：2015-02-03

申请号：US13943019

申请日：2013-07-16

Applicant: Korea Institute of Science and Technology

Inventor： Sun Joon Min ,  Yong Seo Cho ,  Ae Nim Pae ,  Eun Jeong Lim ,  Ji Yeong Kim ,  Myung Hee Son ,  Jae Kyun Lee

IPC: C07D215/06 ,  A61K31/04 ,  C07D215/20 ,  C07D401/06

CPC classification number: C07D215/06 ,  C07D215/20 ,  C07D401/06

Abstract: Provided is a 2-(substituted ethynyl)quinoline derivative having an mGluR5 antagonistic activity and pharmaceutically acceptable salts thereof. The compound of the present invention can be useful as a medicament for treating and preventing mGluR5 receptor-mediated diseases such as Alzheimer's disease, senile dementia, Parkinson's disease, L-DOPA-induced dyskinesia, Huntington's chorea, amyotrophic lateral sclerosis, multiple sclerosis, schizophrenia, anxiety disorder, depression, neuropathic pain, drug dependence, fragile X syndrome, autism, migraine and gastroesophageal reflux disease (GERD).

Abstract translation: 本发明提供具有mGluR5拮抗活性的2-（取代乙炔基）喹啉衍生物及其药学上可接受的盐。 本发明的化合物可用作治疗和预防mGluR5受体介导的疾病如阿尔茨海默氏病，老年性痴呆，帕金森病，L-DOPA诱导的运动障碍，亨廷顿舞蹈病，肌萎缩性侧索硬化，多发性硬化，精神分裂症 ，焦虑症，抑郁症，神经性疼痛，药物依赖，脆性X综合征，自闭症，偏头痛和胃食管反流病（GERD）。