公开(公告)号：US08895602B1

公开(公告)日：2014-11-25

申请号：US14013487

申请日：2013-08-29

Applicant: Korea Institute of Science and Technology

Inventor： Ghil Soo Nam ,  Kyung Il Choi ,  Ae Nim Pae ,  Seon Hee Seo ,  Hyun Ah Choo ,  Gyo Chang Keum ,  Jung Hyun Kim

IPC: A61K31/4155 ,  C07D403/12

CPC classification number: C07D403/12 ,  A61K31/4155

Abstract: The present invention relates to a 6-pyrazolylamido-3-substituted azabicyclo[3.1.0]hexane derivatives useful as calcium channel blockers, pharmaceutically acceptable salts thereof and medical use of the calcium channel inhibiting effect of the compounds for treatment of diseases.

Abstract translation: 本发明涉及可用作钙通道阻滞剂的6-吡唑基氨基-3-取代的氮杂双环[3.1.0]己烷衍生物，其药学上可接受的盐，以及该化合物治疗疾病的钙通道抑制作用的医学应用。

公开(公告)号：US09493423B2

公开(公告)日：2016-11-15

申请号：US14632839

申请日：2015-02-26

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Ghil Soo Nam ,  Kyung Il Choi ,  Jung Hyun Kim ,  Ae Nim Pae ,  Jin Ri Hong ,  Jae Kyun Lee

IPC: C07D231/12 ,  C07D417/14 ,  C07D401/12 ,  C07D417/06

CPC classification number: C07D231/12 ,  C07D401/12 ,  C07D417/06 ,  C07D417/14

Abstract: Disclosed herein are an N-(pyrazolylmethyl)arylsulfonamide derivative useful as a calcium ion channel blocker, a pharmaceutically acceptable salt thereof, and the medicinal use thereof as a therapeutic agent using its calcium ion channel blocking effect.

Abstract translation: 本文公开了可用作钙离子通道阻断剂的N-（吡唑基甲基）芳基磺酰胺衍生物及其药学上可接受的盐，其药物用途为其钙离子通道阻断作用的治疗剂。