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    Pharmaceutical composition for the prevention or treatment of inflammatory diseases or immune diseases containing ramalin
    1.
    发明授权
    Pharmaceutical composition for the prevention or treatment of inflammatory diseases or immune diseases containing ramalin 有权
    用于预防或治疗含有马马隆的炎性疾病或免疫疾病的药物组合物

    公开(公告)号：US09539227B2

    公开(公告)日：2017-01-10

    申请号：US14261551

    申请日：2014-04-25

    申请人： Korea Ocean Research and Development Institute

    发明人： Joung Han Yim ,  Il Chan Kim ,  Sung Gu Lee ,  Doc Kyu Kim ,  Se Jong Han ,  Hyoung Seok Lee ,  Sung Jin Kim ,  Tai Kyoung Kim ,  Pil-Sung Kang ,  Heeyong Park ,  Ha Ju Park ,  Suhkneung Pyo ,  Babita Paudel-Bhattarai

    IPC分类号： A61K31/198 ,  A61K45/06 ,  A61K31/45

    CPC分类号： A61K31/198 ,  A61K31/45 ,  A61K45/06

    摘要： The present invention relates to the novel use (anti-inflammatory activity) of Ramalin isolated from the Antarctic lichen Ramalina terebrata, and more specifically to a pharmaceutical composition containing Ramalin as an active ingredient. Ramalin of the invention is a compound derived from natural material, has no toxicity or side effects, and inhibits the expression of inducible nitric oxide synthase (iNOS) in the transcription stage to significantly inhibit the production of nitric oxide (NO) that is a key mediator of inflammatory responses. In addition, it inhibits the activation of the inflammatory mediator NF-κB, inhibits p38 MAPK, ERK1/2 and JNK signaling pathways, and inhibits the expression of the LPS receptor TLR4, suggesting that Ramalin has an excellent anti-inflammatory effect. Thus, the composition containing Ramalin can be effectively used to fundamentally treat or prevent inflammatory diseases or immune diseases and to relieve or alleviate the symptoms of the diseases.

    摘要翻译： 本发明涉及从南极地衣Ramalina terebrata分离的Ramalin的新用途（抗炎活性），更具体地涉及含有Ramalin作为活性成分的药物组合物。 本发明的Ramalin是衍生自天然材料的化合物，没有毒性或副作用，并且在转录期抑制诱导型一氧化氮合酶（iNOS）的表达，以显着抑制作为关键的一氧化氮（NO）的产生 炎症反应的介质。 此外，它抑制炎症介质NF-κB的活化，抑制p38 MAPK，ERK1 / 2和JNK信号通路，并抑制LPS受体TLR4的表达，提示Ramalin具有优异的抗炎作用。 因此，含有Ramalin的组合物可以有效地用于从根本上治疗或预防炎性疾病或免疫疾病，并缓解或缓解疾病的症状。