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公开(公告)号：US11624087B2
公开(公告)日：2023-04-11
申请号：US16917135
申请日：2020-09-22
Inventor： Jieon Lee , Woo-keun Kim , Sangwoo Lee , Seokjoo Yoon
IPC: C12Q1/682
Abstract: The present invention relates to a composition for detecting nucleic acid comprising duplex molecular beacon and graphene oxide and a colorimetric signal enhancement method of detecting nucleic acid using the same. According to the composition, kit and method for detecting nucleic acid of the present invention, a complex can be formed by adsorbing a single strand having a DNAzyme sequence dissociated from the conjugate of a duplex molecular beacon and a target nucleic acid to the graphene oxide surface, and separated, and a colorimetric signal amplified therefrom can be induced, so that a very low concentration of target nucleic acid can be detected with high efficiency and the target nucleic acid can be detected quickly and easily in seconds. Therefore, a new colorimetric target nucleic acid detection system capable of point of care testing (POCT) can be provided.
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公开(公告)号：US11166891B2
公开(公告)日：2021-11-09
申请号：US16562298
申请日：2019-09-05
Inventor： Woo-Keun Kim , Sangwoo Lee , Seokjoo Yoon , Chul Min Park
IPC: C07C43/215 , A61K8/33 , C07C43/285 , C07C41/30 , A23L33/10 , A61Q19/02
Abstract: The present invention relates to a bis phenyl hexa triene derivative, a preparation method thereof and a composition for skin whitening comprising the same as an active ingredient. The said derivative inhibits the expression of tyrosinase, TRP 1 (tyrosinase-related protein 1), TRP 2 (tyrosinase-related protein 2) or MITF (microphthalmia-associated transcription factor) gene which produces a precursor necessary for the generation of melanin, suppresses the activity of tyrosinase, eventually inhibits the biosynthesis of melanin, is safe due to low cytotoxicity, and has less side effects and excellent antioxidative effect, so that it can be effectively used as a composition for skin whitening.
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