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1.发明申请PHOSPHINE COMPOUND, PROCESS FOR PRODUCING THE SAME, AND PEROXIDE SCAVENGER USING THE SAME 有权磷酸酯化合物，其制造方法和使用其的过氧化物螯合剂公开(公告)号：US20110015440A1
公开(公告)日：2011-01-20
申请号：US12921967
申请日：2009-03-10
申请人： Kosei Shioji , Hiroyuki Nakagawa , Kentaro Okuma
发明人： Kosei Shioji , Hiroyuki Nakagawa , Kentaro Okuma
IPC分类号： C07F9/54
CPC分类号： C07F9/5442 , C07F9/5325
摘要： The invention provides a novel peroxide scavenger comprising a phosphine compound represented by general formula [I]: wherein Z1 and Z2 each represents a cyclic group; Ar represents an arylene group; R represents an aliphatic hydrocarbon group; Y represents phosphorus (P), nitrogen (N), or bismuth (Bi); and R1, R2, and R3 each represents a cyclic group, particularly a peroxide scavenger that can scavenge peroxides such as reactive oxygen species which are generated in mitochondria upon exposure to oxidative stress and localized in mitochondria. The phosphine compound of the invention is oxidized by the peroxides localized in mitochondria to increase the fluorescence intensity, whereby the peroxides can be scavenged.
摘要翻译： 本发明提供了一种新型的过氧化物清除剂，其包含由通式[I]表示的膦化合物：其中Z1和Z2各自表示环状基团; Ar表示亚芳基; R表示脂族烃基; Y表示磷（P），氮（N）或铋（Bi）; R1，R2和R3各自表示环状基团，特别是可以清除在暴露于氧化应激并且局限于线粒体中在线粒体中产生的过氧化物如活性氧的过氧化物清除剂。 本发明的膦化合物被定位在线粒体中的过氧化物氧化以增加荧光强度，从而可以清除过氧化物。
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2.发明授权Phosphine compound, process for producing the same, and peroxide scavenger using the same 有权膦化合物，其制备方法和使用该化合物的过氧化物清除剂公开(公告)号：US08420865B2
公开(公告)日：2013-04-16
申请号：US12921967
申请日：2009-03-10
申请人： Kosei Shioji , Hiroyuki Nakagawa , Kentaro Okuma
发明人： Kosei Shioji , Hiroyuki Nakagawa , Kentaro Okuma
IPC分类号： C07F9/54
CPC分类号： C07F9/5442 , C07F9/5325
摘要： The invention provides a novel peroxide scavenger comprising a phosphine compound represented by general formula [I]: wherein Z1 and Z2 each represents a cyclic group; Ar represents an arylene group; R represents an aliphatic hydrocarbon group; Y represents phosphorus (P), nitrogen (N), or bismuth (Bi); and R1, R2, and R3 each represents a cyclic group, particularly a peroxide scavenger that can scavenge peroxides such as reactive oxygen species which are generated in mitochondria upon exposure to oxidative stress and localized in mitochondria. The phosphine compound of the invention is oxidized by the peroxides localized in mitochondria to increase the fluorescence intensity, whereby the peroxides can be scavenged.
摘要翻译： 本发明提供了一种新型的过氧化物清除剂，其包含由通式[I]表示的膦化合物：其中Z1和Z2各自表示环状基团; Ar表示亚芳基; R表示脂族烃基; Y表示磷（P），氮（N）或铋（Bi）; R1，R2和R3各自表示环状基团，特别是可以清除在暴露于氧化应激并且局限于线粒体中在线粒体中产生的过氧化物如活性氧的过氧化物清除剂。 本发明的膦化合物被定位在线粒体中的过氧化物氧化以增加荧光强度，从而可以清除过氧化物。
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