公开(公告)号：US20040023968A1

公开(公告)日：2004-02-05

申请号：US10426147

申请日：2003-04-29

申请人： KuDOS Pharmaceuticals Limited ,  Maybridge plc

发明人： Niall Morrison Barr Martin ,  Graeme Cameron Murray Smith ,  Penny Jane Eversley ,  Xiao-Ling Cockcroft ,  Frank Kerrigan ,  Janet Hoare ,  Lesley Dixon

IPC分类号： A61K031/502 ,  C07D43/02

CPC分类号： C07D401/10 ,  C07D237/32 ,  C07D403/10 ,  C07D495/04

摘要： A compound of formula: 1 or an isomer, salt, solvate, chemically protected form, or prodrug thereof, wherein A and B together represent an optionally substituted, fused aromatic ring; RL is a C5-7 aryl group substituted in the meta position by the group R2, and optionally further substituted; wherein R2 is selected from: 2 and its use as a pharmaceutical, in particular for the treatment of diseases ameliorated by inhibiting the activity of PARP.

摘要翻译： 下式化合物或其异构体，盐，溶剂合物，化学保护形式或前药，其中A和B一起表示任选取代的稠合芳环; R L是由R 2基团在间位取代的任选进一步取代的C 5-7芳基; 其中R 2选自：及其作为药物的用途，特别是用于治疗通过抑制PARP的活性而改善的疾病。