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    Laminar structure for administering a chemical at a controlled release rate
    1.
    发明授权
    Laminar structure for administering a chemical at a controlled release rate 失效
    用于以控制释放速率施用化学品的层状结构

    公开(公告)号：US4931281A

    公开(公告)日：1990-06-05

    申请号：US322605

    申请日：1989-03-10

    申请人： Kwon H. Kim ,  Norman L. Henderson ,  Yie W. Chien

    发明人： Kwon H. Kim ,  Norman L. Henderson ,  Yie W. Chien

    IPC分类号： A61K9/70 ,  A61L15/16 ,  A61M31/00 ,  A61M35/00

    CPC分类号： A61K9/7084 ,  A61M31/002

    摘要： A laminar structure for administering a chemical at a controlled release rate is disclosed. The structure comprises a backing member which acts as a boundary through which the chemical does not pass. Contacting at least a portion of the backing member is a chemical containing layer having therein a first chemical portion and a second chemical portion. The first and second chemical portions comprise a mixture of chemical in a first concentration transport mode and a second concentration transport mode. The mixture being in a ratio to give a desired chemical release rate from the chemical containing layer.

    摘要翻译： 公开了一种用于以控制释放速率施用化学物质的层状结构。 该结构包括作为化学品不通过的边界的背衬构件。 接触背衬构件的至少一部分是其中具有第一化学部分和第二化学部分的化学容纳层。 第一和第二化学部分包括在第一浓度输送模式和第二浓度输送模式中的化学物质的混合物。 该混合物的比例是从含化学物质层得到期望的化学品释放速率。

    Transnasal anticonvulsive compositions and modulated process
    3.
    发明授权
    Transnasal anticonvulsive compositions and modulated process 失效
    经鼻抗惊厥组合物和调节过程

    公开(公告)号：US06627211B1

    公开(公告)日：2003-09-30

    申请号：US09624305

    申请日：2000-07-24

    申请人： Yong Moon Choi ,  Lianli Li ,  Kwon H. Kim

    发明人： Yong Moon Choi ,  Lianli Li ,  Kwon H. Kim

    IPC分类号： A61F1300

    CPC分类号： A61K9/0043 ,  A61K47/10 ,  A61K47/24 ,  A61K47/28 ,  Y10S514/975

    摘要： A method of vehicle modulated administration of an anticonvulsive agent to the nasal mucous membranes of humans and animals is disclosed. The vehicle system is an aqueous pharmaceutical carrier comprising an aliphatic alcohol, a glycol and a biological surfactant such as a bile salt or a lecithin. The pharmaceutical composition provides a means to control and promote the rate and extent of transmucosal permeation and absorption of the medicaments via a single and multiple administration. Nasal administration of the pharmaceutical preparation produces a high plasma concentration of the anticonvulsant nearly as fast as intravenous administration. Such compositions are particularly suitable for a prompt and timely medication of patients in the acute and/or emergency treatment of status epilepticus and other fever-induced seizures.

    摘要翻译： 公开了一种向人和动物的鼻粘膜施用抗惊厥药的车辆调节方法。 载体系统是包含脂族醇，二醇和生物表面活性剂如胆汁盐或卵磷脂的水性药物载体。 药物组合物通过单次和多次施用提供控制和促进药物经粘膜渗透和吸收的速率和程度的手段。 药物制剂的鼻内给药几乎与静脉内施用一样快地产生抗惊厥药的高血浆浓度。 这种组合物特别适用于急性和/或紧急治疗癫痫持续状态和其他发热引起的发作的患者的及时和及时的药物。

    Transnasal anticonvulsive compositions and modulated process
    4.
    发明授权
    Transnasal anticonvulsive compositions and modulated process 失效
    经鼻抗惊厥组合物和调节过程

    公开(公告)号：US07132112B2

    公开(公告)日：2006-11-07

    申请号：US10634689

    申请日：2003-08-05

    申请人： Yong Moon Choi ,  Lianli Li ,  Kwon H. Kim

    发明人： Yong Moon Choi ,  Lianli Li ,  Kwon H. Kim

    IPC分类号： A61F13/00 ,  A61L9/04

    CPC分类号： A61K9/0043 ,  A61K47/10 ,  A61K47/24 ,  A61K47/28 ,  Y10S514/975

    摘要： A novel method of vehicle modulated administration of an anticonvulsive agent to the mucous membranes of humans and animals is disclosed. The vehicle system is an aqueous pharmaceutical carrier comprising an aliphatic alcohol (10–80%) or a glycol (10–80%), and their combinations with a biological surfactant such as a bile salt or a lecithin. The pharmaceutical composition provides a means to control and promote the rate and extent of transmucosal permeation and absorption of the medicaments via a single and multiple administration. Nasal administration of the pharmaceutical preparation produces a high plasma concentration of the anticonvulsant nearly as fast as intravenous administration. Such compositions are particularly suitable for a prompt and timely medication of patients in the acute and/or emergency treatment of status epilepticus and other fever-induced seizures.

    摘要翻译： 公开了一种抗人惊厥剂对人和动物粘膜的车辆调节施用的新方法。 载体系统是包含脂族醇（10-80％）或二醇（10-80％））及其与生物表面活性剂如胆汁盐或卵磷脂的组合的水性药物载体。 药物组合物通过单次和多次施用提供控制和促进药物经粘膜渗透和吸收的速率和程度的手段。 药物制剂的鼻内给药几乎与静脉内施用一样快地产生抗惊厥药的高血浆浓度。 这种组合物特别适用于急性和/或紧急治疗癫痫持续状态和其他发热引起的发作的患者的及时和及时的药物。