公开(公告)号：US20220411752A1

公开(公告)日：2022-12-29

申请号：US17773467

申请日：2020-10-30

申请人： Kyoto University ,  Takeda Pharmaceutical Company Limited

发明人： Shin KANEKO ,  Hisashi YANO ,  Tokuyuki SHINOHARA

IPC分类号： C12N5/0783 ,  C12N15/90

摘要： Provided is an excellent method for producing an IL-4 non-secreting and IFN-γ secreting (Th1-type) or IFN-γ non-secreting and IL-4 secreting (Th2-type) CD4 single-positive T cell (CD4SP T cell). The method for producing the Th1-type or Th2-type CD4SP T cell of the present invention comprises a step of inducing a CD4 single-positive T cell from a hematopoietic stem cell (HSC) and/or a hematopoietic progenitor cell (HPC) substantially defective in a factor involved in IL-4 secretion or a factor involved in IFN-γ secretion.