公开(公告)号：US20080044657A1

公开(公告)日：2008-02-21

申请号：US11642772

申请日：2006-12-19

申请人： Kyoungja Woo ,  Dong Hyun Koo

发明人： Kyoungja Woo ,  Dong Hyun Koo

IPC分类号： B32B1/00 ,  B05D7/00 ,  B32B15/02

CPC分类号： B82Y30/00 ,  A61K49/0052 ,  A61K49/0054 ,  A61K49/0067 ,  B82Y5/00 ,  Y10S977/827 ,  Y10S977/83 ,  Y10T428/2998

摘要： There is provided an organic-inorganic composite material containing a single nanoparticle therein, which is prepared by individually dispersing hydrophilic inorganic nanoparticles having a uniform particle size and conjugating biodegradable polymers to the surface of the nanoparticle, and a method of preparing the same. More particularly, the preparation method of the present invention comprises the following steps: 1) preparing hydrophilic nanoparticles by conjugating organic substances having a thiol group and a hydrophilic amine group to the surface of a core or a core/shell inorganic nanoparticle protected with a surfactant through a metal-thiolate (M-S) bond between them; 2) adjusting the concentration of the hydrophilic nanoparticles prepared in step 1) to 2×10−6 M or less and treating them in a sonication bath to prepare individually dispersed nanoparticles in the form of a single particle; and 3) conjugating biopolymers to the nanoparticle individually dispersed in step 2) through the formation of an amide bond between them under treatment in a sonication bath. The organic-inorganic composite material of the present invention exhibits high efficient photoluminescence and photostability as well as excellent chemical stability, dispersibility in water, biocompatibility and targetibility. Thus, it can be effectively used as a raw material for bioimaging or film coating.

摘要翻译： 提供一种其中含有单一纳米颗粒的有机 - 无机复合材料，其通过将具有均匀粒度的亲水性无机纳米颗粒和将可生物降解的聚合物共轭分散在纳米颗粒的表面上而制备，及其制备方法。 更具体地说，本发明的制备方法包括以下步骤：1）通过将具有硫醇基和亲水性胺基的有机物质缀合到核表面或用表面活性剂保护的核/壳无机纳米颗粒的表面制备亲水性纳米颗粒 通过它们之间的金属硫醇盐（MS）键; 2）将步骤1）中制备的亲水性纳米颗粒的浓度调节至2×10 -6 M或更小，并在超声处理浴中处理它们以制备单一颗粒形式的单独分散的纳米颗粒; 和3）将生物聚合物与步骤2）中分散分散的纳米颗粒共轭，通过在超声处理浴中处理之间通过它们之间形成酰胺键。 本发明的有机 - 无机复合材料显示出高效的光致发光和光稳定性以及优异的化学稳定性，在水中的分散性，生物相容性和可目标性。 因此，其可以有效地用作生物成像或薄膜包衣的原料。

公开(公告)号：US07601391B2

公开(公告)日：2009-10-13

申请号：US11642772

申请日：2006-12-19

申请人： Kyoungja Woo ,  Dong Hyun Koo

发明人： Kyoungja Woo ,  Dong Hyun Koo

IPC分类号： B05D7/00 ,  B06B1/00 ,  B32B5/16

CPC分类号： B82Y30/00 ,  A61K49/0052 ,  A61K49/0054 ,  A61K49/0067 ,  B82Y5/00 ,  Y10S977/827 ,  Y10S977/83 ,  Y10T428/2998

摘要： There is provided an organic-inorganic composite material containing a single nanoparticle therein, which is prepared by individually dispersing hydrophilic inorganic nanoparticles having a uniform particle size and conjugating biodegradable polymers to the surface of the nanoparticle, and a method of preparing the same. More particularly, the preparation method of the present invention comprises the following steps: 1) preparing hydrophilic nanoparticles by conjugating organic substances having a thiol group and a hydrophilic amine group to the surface of a core or a core/shell inorganic nanoparticle protected with a surfactant through a metal-thiolate (M-S) bond between them; 2) adjusting the concentration of the hydrophilic nanoparticles prepared in step 1) to 2×10−6 M or less and treating them in a sonication bath to prepare individually dispersed nanoparticles in the form of a single particle; and 3) conjugating biopolymers to the nanoparticle individually dispersed in step 2) through the formation of an amide bond between them under treatment in a sonication bath. The organic-inorganic composite material of the present invention exhibits high efficient photoluminescence and photostability as well as excellent chemical stability, dispersibility in water, biocompatibility and targetibility. Thus, it can be effectively used as a raw material for bioimaging or film coating.

摘要翻译： 提供一种其中含有单一纳米颗粒的有机 - 无机复合材料，其通过将具有均匀粒度的亲水性无机纳米颗粒和将可生物降解的聚合物共轭分散在纳米颗粒的表面上而制备，及其制备方法。 更具体地说，本发明的制备方法包括以下步骤：1）通过将具有硫醇基和亲水性胺基的有机物质缀合到核表面或用表面活性剂保护的核/壳无机纳米颗粒的表面制备亲水性纳米颗粒 通过它们之间的金属硫醇盐（MS）键; 2）将步骤1）中制备的亲水性纳米颗粒的浓度调节至2×10 -6 M或更小，并在超声处理浴中处理以制备单个颗粒形式的单独分散的纳米颗粒; 和3）将生物聚合物与步骤2）中分散分散的纳米颗粒共轭，通过在超声处理浴中处理之间通过它们之间形成酰胺键。 本发明的有机 - 无机复合材料显示出高效的光致发光和光稳定性以及优异的化学稳定性，在水中的分散性，生物相容性和可目标性。 因此，其可以有效地用作生物成像或薄膜包衣的原料。