公开(公告)号：US20240131178A1

公开(公告)日：2024-04-25

申请号：US18285194

申请日：2022-03-30

Applicant: LEGOCHEM BIOSCIENCES, INC. ,  NONA BIOSCIENCES (SUZHOU) CO., LTD.

Inventor： Chang Sik PARK ,  Ho Young SONG ,  Tae Ik JANG ,  Chul-Woong CHUNG ,  Ming-jin JHENG

IPC: A61K47/68 ,  A61K47/54 ,  A61P35/00

CPC classification number: A61K47/6849 ,  A61K47/545 ,  A61K47/549 ,  A61K47/68031 ,  A61K47/68035 ,  A61P35/00

Abstract: The present disclosure relates to a novel antibody-drug conjugate (ADC) targeting claudin 18 isoform 2 (CLDN18.2), an active metabolite of the ADC, a method of producing the ADC, use of the ADC for the treatment and/or prevention of diseases, and use of the ADC for producing a drug for the treatment and/or prevention of diseases, more specifically hyperproliferative and/or angiogenic diseases, for example, cancer, and more particularly, to an antibody-drug conjugate including a novel antibody or antigen-binding fragment thereof that binds to CLDN18.2, and a pharmaceutical composition including the same.