公开(公告)号：US20150297616A1

公开(公告)日：2015-10-22

申请号：US14648480

申请日：2013-11-28

Applicant: LEO PHARMA A/S

Inventor： Paola LOVATO

IPC: A61K31/59 ,  A61K31/44 ,  A61K45/06

CPC classification number: A61K31/59 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/593 ,  A61K45/06 ,  A61K2300/00

Abstract: The present invention relates to a method of inhibiting the upregulation of the expression of the proinflammatory cytokine interleukin-22 (IL-22) in activated and differentiated human T-cells, said upregulation being induced by administration of a therapeutically effective amount of a phosphodiesterase 4 (PDE4) inhibitor. The method comprises administering, either sequentially to or simultaneously with the administration of the PDE4 inhibitor, a vitamin D receptor agonist in an amount 3) sufficient to inhibit the upregulation of IL-22 expression.

Abstract translation: 本发明涉及抑制活化和分化的人T细胞中促炎细胞因子白细胞介素-22（IL-22）表达上调的方法，所述上调是通过施用治疗有效量的磷酸二酯酶4 （PDE4）抑制剂。 该方法包括向PDE4抑制剂的依次施用或同时施用足以抑制IL-22表达上调的量3）的维生素D受体激动剂。