公开(公告)号：US12043669B2

公开(公告)日：2024-07-23

申请号：US18507579

申请日：2023-11-13

Applicant: LEO Pharma A/S

Inventor： Birgitte Ursø ,  Waseem Sajid ,  Paola Lovato ,  Heidi Westh Bagger ,  Christoph Erkel ,  Petra Nussbaumer ,  Simon Schuster

IPC: C07K16/28 ,  A61K39/00

CPC classification number: C07K16/2866 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present disclosure provides novel antibodies and fragments thereof targeting IL-1RAcP (Interleukin-1 receptor accessory protein). Use of IL-1RAcP inhibitors are also provided herein.

公开(公告)号：US09855285B2

公开(公告)日：2018-01-02

申请号：US14648480

申请日：2013-11-28

Applicant: LEO PHARMA A/S

Inventor： Paola Lovato

IPC: A61K31/59 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/593 ,  A61K45/06

CPC classification number: A61K31/59 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/593 ,  A61K45/06 ,  A61K2300/00

Abstract: The present invention relates to a method of inhibiting the upregulation of the expression of the proinflammatory cytokine interleukin-22 (IL-22) in activated and differentiated human T-cells, said upregulation being induced by administration of a therapeutically effective amount of a phosphodiesterase 4 (PDE4) inhibitor. The method comprises administering, either sequentially to or simultaneously with the administration of the PDE4 inhibitor, a vitamin D receptor agonist in an amount sufficient to inhibit the upregulation of IL-22 expression.

公开(公告)号：US20240190977A1

公开(公告)日：2024-06-13

申请号：US18507579

申请日：2023-11-13

Applicant: LEO Pharma A/S

Inventor： Birgitte Ursø ,  Waseem Sajid ,  Paola Lovato ,  Heidi Westh Bagger ,  Christoph Erkel ,  Petra Nussbaumer ,  Simon Schuster

IPC: C07K16/28 ,  A61K39/00

CPC classification number: C07K16/2866 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present disclosure provides novel antibodies and fragments thereof targeting IL-1RAcP (Interleukin-1 receptor accessory protein). Use of IL-1RAcP inhibitors are also provided herein.

公开(公告)号：US20220411517A1

公开(公告)日：2022-12-29

申请号：US17664349

申请日：2022-05-20

Applicant: LEO Pharma A/S

Inventor： Birgitte Ursø ,  Waseem Sajid ,  Paola Lovato ,  Heidi Westh Bagger ,  Christoph Erkel ,  Petra Nussbaumer ,  Simon Schuster

IPC: C07K16/28

Abstract: The present disclosure provides novel antibodies and fragments thereof targeting IL-1RAcP. Use of IL-1RAcP inhibitors are also provided herein.