公开(公告)号：US20160009751A1

公开(公告)日：2016-01-14

申请号：US14330808

申请日：2014-07-14

Applicant: LEO Pharma A/S

Inventor： Michael L. SIERRA ,  Jakob FELDING ,  Qianghui ZHOU ,  Hans RENATA ,  Philippe S. BARAN

IPC: C07J7/00 ,  C07J21/00 ,  A61K31/573

CPC classification number: C07J7/0085 ,  A61K31/573 ,  A61K45/06 ,  C07J21/006

Abstract: The present invention relates to a compound according to formula I wherein R1 is selected from the group consisting of hydrogen and fluoro and R2 is selected from C1-C4 alkyl and hydrates or solvates thereof. The invention further relates to intermediates for the preparation of said compounds, to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases with said compounds, and to the use of said compounds in the manufacture of medicaments.

Abstract translation: 本发明涉及式Ⅰ化合物，其中R 1选自氢和氟，R 2选自C 1 -C 4烷基及其水合物或溶剂合物。 本发明还涉及用于制备所述化合物的中间体，用于治疗的所述化合物，包含所述化合物的药物组合物，用所述化合物治疗疾病的方法，以及所述化合物在制备药物中的用途。