公开(公告)号：US11447480B2

公开(公告)日：2022-09-20

申请号：US17054084

申请日：2019-05-08

申请人： LG CHEM, LTD.

发明人： Young Kwan Kim ,  Ohhwan Kwon ,  Heedong Park ,  Junggyu Park ,  Hwan Geun Choi ,  Jung Beom Son ,  Eunhwa Ko ,  So Young Kim ,  Seungyeon Lee ,  Seock Yong Kang ,  Yi Kyung Ko ,  Jin-Hee Park

IPC分类号： C07D417/04 ,  C07D277/56 ,  C07D277/82

摘要： The present invention relates to a novel compound exhibiting enteropeptidase-inhibiting activity, a pharmaceutically acceptable salt thereof, a pharmaceutical composition for preventing and treating metabolic diseases such as obesity, diabetes mellitus or hyperlipidemia, etc. comprising the compound or pharmaceutically acceptable salt, and a method for preventing or treating metabolic disease using the above novel compound. The compound of the present invention has excellent inhibitory activity against enteropeptidase, and thus is not absorbed into the body, but are excreted outside the body. However, since not only fat but also protein are discharged together, it has few side effects such as fat stools and acts only in the gastrointestinal tract, so it has few side effects such as depression, and is very useful as a therapeutic or prophylactic drug for various metabolic diseases such as obesity, diabetes mellitus, and hyperlipidemia.