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公开(公告)号：US09937261B2
公开(公告)日：2018-04-10
申请号：US15317842
申请日：2015-06-09
发明人： Alberto Gabizon , Patricia Ohana , Andrew Wang
IPC分类号： A61K9/127 , A61K47/48 , A61K31/407
CPC分类号： A61K47/543 , A61K9/0019 , A61K9/0053 , A61K9/127 , A61K31/337 , A61K31/407 , A61K31/513 , A61K31/704 , A61K31/7068 , A61K45/06 , A61K47/6911 , A61K2300/00
摘要： A method of treating neoplasia in a subject in need of treatment is provided by administering to the subject an amount of a prodrug of mitomycin C that yields a therapeutically effective amount of mitomycin C, in combination with radiation therapy. In one embodiment, the prodrug of mitomycin C is a liposomal-prodrug of mitomycin C. Together, the prodrug of mitomycin C and radiation therapy provide a synergistic antineoplastic effect.
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公开(公告)号：US20170119895A1
公开(公告)日：2017-05-04
申请号：US15317842
申请日：2015-06-09
发明人： Alberto Gabizon , Patricia Ohana , Andrew Wang
IPC分类号： A61K31/407 , A61K9/127
CPC分类号： A61K47/543 , A61K9/0019 , A61K9/0053 , A61K9/127 , A61K31/337 , A61K31/407 , A61K31/513 , A61K31/704 , A61K31/7068 , A61K45/06 , A61K47/6911 , A61K2300/00
摘要： A method of treating neoplasia in a subject in need of treatment is provided by administering to the subject an amount of a prodrug of mitomycin C that yields a therapeutically effective amount of mitomycin C, in combination with radiation therapy. In one embodiment, the prodrug of mitomycin C is a liposomal-prodrug of mitomycin C. Together, the prodrug of mitomycin C and radiation therapy provide a synergistic antineoplastic effect.
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公开(公告)号：US20180071253A1
公开(公告)日：2018-03-15
申请号：US15559395
申请日：2016-03-17
发明人： Alberto Gabizon , Patricia Ohana
IPC分类号： A61K31/407 , A61K9/127 , A61K9/00
CPC分类号： A61K31/407 , A61K9/0034 , A61K9/1271
摘要： The present disclosure related to a method of treating bladder cancer in a subject in need of treatment, by administering to the subject an amount of a prodrug of mitomycin C that yields a therapeutically effective amount of mitomycin C. In one embodiment, the prodrug of mitomycin C is a liposomal-prodrug of mitomycin C. In another embodiment, the liposomal-prodrug of mitomycin C is a folate-targeted liposomal-prodrug of mitomycin C.
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4.发明申请公开(公告)号：US20220087975A1
公开(公告)日：2022-03-24
申请号：US17421959
申请日：2020-01-11
发明人： Alberto Gabizon , Patricia Ohana , Hilary Shmeeda
IPC分类号： A61K31/407 , A61K9/16 , A61K9/127 , A61K47/24 , A61P35/00
摘要： A liposome composition comprising a lipophilic prodrug of mitomycin C having an improved pharmacokinetic profile is described. A method for preparing the composition with a solvent system comprised of ethanol and tertiary butanol mixed at an adequate ratio is also described. In an embodiment, the liposome composition is a population of lipid nanoparticles and a pharmaceutically acceptable vehicle, wherein the population of lipid nanoparticles is comprised of a first fraction of spherical liposomes and a second fraction of rod-shaped lipid nanoparticles, where the second fraction is less than about 15% of the population of lipid nanoparticles.
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公开(公告)号：US10080807B2
公开(公告)日：2018-09-25
申请号：US15317779
申请日：2015-06-09
发明人： Alberto Gabizon , Patricia Ohana , Hilary Shmeeda
IPC分类号： A61K31/337 , A61K47/54 , A61K9/127 , A61K45/06 , A61K31/407 , A61K31/513 , A61K31/704 , A61K31/7068 , A61K9/00 , A61K47/69
CPC分类号： A61K47/543 , A61K9/0019 , A61K9/0053 , A61K9/127 , A61K31/337 , A61K31/407 , A61K31/513 , A61K31/704 , A61K31/7068 , A61K45/06 , A61K47/6911 , A61K2300/00
摘要： The present invention is based on a finding of an unexpected synergistic and safe combination of antineoplastic agents which when administered in combination provides greater efficacy than the single agents alone. Accordingly, a method of treating neoplasia in a subject in need of treatment is provided, by administering to the subject an amount of a prodrug of mitomycin C that yields a therapeutically effective amount of mitomycin C, in combination with an amount of a chemotherapeutic agent. In one embodiment, the prodrug of mitomycin C is a liposomal-prodrug of mitomycin C. Together, the prodrug of mitomycin C and chemotherapeutic agent provide a synergistic antineoplastic effect.
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公开(公告)号：US20170112807A1
公开(公告)日：2017-04-27
申请号：US15317779
申请日：2015-06-09
发明人： Alberto Gabizon , Patricia Ohana , Hilary Shmeeda
IPC分类号： A61K31/407 , A61K9/127 , A61K9/00 , A61K31/337 , A61K31/7068 , A61K31/513 , A61K45/06 , A61K31/704
CPC分类号： A61K47/543 , A61K9/0019 , A61K9/0053 , A61K9/127 , A61K31/337 , A61K31/407 , A61K31/513 , A61K31/704 , A61K31/7068 , A61K45/06 , A61K47/6911 , A61K2300/00
摘要： The present invention is based on a finding of an unexpected synergistic and safe combination of antineoplastic agents which when administered in combination provides greater efficacy than the single agents alone. Accordingly, a method of treating neoplasia in a subject in need of treatment is provided, by administering to the subject an amount of a prodrug of mitomycin C that yields a therapeutically effective amount of mitomycin C, in combination with an amount of a chemotherapeutic agent. In one embodiment, the prodrug of mitomycin C is a liposomal-prodrug of mitomycin C. Together, the prodrug of mitomycin C and chemotherapeutic agent provide a synergistic antineoplastic effect.
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