公开(公告)号：US3705161A

公开(公告)日：1972-12-05

申请号：US3705161D

申请日：1970-07-27

Applicant: LITTLE INC A

Inventor： RAZDAN RAJ K ,  JOHNSON FATIMA N

IPC: C07D401/04 ,  C07D403/04 ,  C07D413/04 ,  C07D51/70

CPC classification number: C07D401/04 ,  C07D403/04 ,  C07D413/04

Abstract: 5-HYDROXY-4-SATURATED HETEROCYCLIC AMINO-1,2,2A,3,4,5HEXAHYDROBENZ(C,D)INDOLES ARE PREPARED BY AMINATION OF 1-BENZOYL -4,5 - EPOXY - 1,2,2A,3,4,5-HEXAHYDROBENZ(C,D) INDOLE WITH AN APPROPRIATE SECONDARY AMINO FOLLOWED BY DEBENZOYLATION AND IN TURN ARE CONVERTED, IF DESIRED, TO THE CORRESPONDING TETRAHYDRO COMPOUNDS BY DEHYDROGENATION. THE COMPOUNDS ARE USEFUL AS CENTRAL NERVOUS SYSTEM DEPRESSANTS.

公开(公告)号：US3575989A

公开(公告)日：1971-04-20

申请号：US3575989D

申请日：1968-04-23

Applicant: LITTLE INC A

Inventor： RAZDAN RAJ K ,  JOHNSON FATIMA N

IPC: C07D401/04 ,  C07D403/04 ,  C07D413/04 ,  C07D29/28

CPC classification number: C07D401/04 ,  C07D403/04 ,  C07D413/04

Abstract: 5-HYDROXY-4-SATURATED HETEROCYCLIC AMINO-1,2,2A, 3,4,5-HEXANHYDROBENZ(CD)INDOLES ARE PREPARED BY AMINATION OF 1-BENZYOYL-4,5-EPOXY-1,2,2A,3,4,5-HEXAHYDROBENZ(CD)INDOLE WITH AN APPROPRIATE SECONDARY AMINE FOLLOWED BY DEBENZOYLATION AND IN TURN ARE CONVERTED, IF DESIRED, TO THE CORRESPONDING TETRAHYDRO COMPOUNDS BY DEHYDROGENATION. THE COMPOUNDS ARE USEFUL AS CENTRAL NERVOUS SYSTEM DEPRESSANTS.