专利检索 ap:("LUOXIN PHARMACEUTICAL (SHANGHAI) CO., LTD." OR "SHANDONG LUOXIN PHARMACEUTICAL GROUP STOCK CO., LTD.") AND inv:"Xu Zeng" 第 1 页

1.

发明授权
Indolo substituted piperidine compound as estrogen receptor down-regulator 有权

公开(公告)号：US10774081B2

公开(公告)日：2020-09-15

申请号：US16345271

申请日：2017-10-30

申请人： LUOXIN PHARMACEUTICAL (SHANGHAI) CO., LTD. , SHANDONG LUOXIN PHARMACEUTICAL GROUP STOCK CO., LTD.

发明人： Jianyu Lu , Charles Z. Ding , Xu Zeng , Huijun He , Shuhui Chen , Lihong Hu , Jiaqiang Dong , Tie-Lin Wang

IPC分类号： C07D471/04 , A61P35/00

摘要： Disclosed in the present invention is a type of indole substituted piperidine compounds as an estrogen receptor down-regulator. Specifically disclosed are a compound as shown in formula (I), a pharmaceutically acceptable salt, hydrate or prodrug thereof, a preparation method therefor, a pharmaceutical composition thereof, and a use thereof as an estrogen receptor down-regulator in the treatment of estrogen receptor positive breast cancers.