公开(公告)号：US20170112840A1

公开(公告)日：2017-04-27

申请号：US15400627

申请日：2017-01-06

申请人： LUPIN LIMITED

发明人： Bhavesh DAVE ,  Rakesh Kumar BANERJEE ,  Samiron PHUKAN ,  Abhijit Datta KHOJE ,  Rajkumar HANGARGE ,  Jitendra Sambhaji JADHAV ,  Venkata P. PALLE ,  Rajender Kumar KAMBOJ

IPC分类号： A61K31/519 ,  A61K45/06

CPC分类号： C07D471/04 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06 ,  A61N5/10

摘要： The present invention is related to heteroaryl compounds as MEK inhibitors. The invention includes heteroaryl compounds of formula I, their tautomers and pharmaceutically acceptable salts, combinations with suitable medicament and pharmaceutical compositions thereof. The present invention also includes process of preparation of the said compounds and intended use in therapy of them.

公开(公告)号：US20150299186A1

公开(公告)日：2015-10-22

申请号：US14385106

申请日：2013-03-11

申请人： LUPIN LIMITED

发明人： Bhavesh DAVE ,  Rakesh Kumar BANERJEE ,  Samiron PHUKAN ,  Abhijit Datta KHOJE ,  Rajkumar HANGARGE ,  Jitendra Sambhaji JADHAV ,  Venkata P. PALLE ,  Rajender Kumar KAMBOJ

IPC分类号： C07D471/04 ,  A61K45/06 ,  A61N5/10 ,  A61K31/519

CPC分类号： C07D471/04 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06 ,  A61N5/10

摘要： The present invention is related to heteroaryl compounds as MEK inhibitors. The invention includes heteroaryl compounds of formula I, their tautomers and pharmaceutically acceptable salts, combinations with suitable medicament and pharmaceutical compositions thereof. The present invention also includes process of preparation of the said compounds and intended use in therapy of them.

摘要翻译： 本发明涉及作为MEK抑制剂的杂芳基化合物。 本发明包括式I的杂芳基化合物，其互变异构体和药学上可接受的盐，与合适的药物及其药物组合物的组合。 本发明还包括制备所述化合物的方法和用于治疗它们的预期用途。

公开(公告)号：US20170101408A1

公开(公告)日：2017-04-13

申请号：US15388327

申请日：2016-12-22

申请人： LUPIN LIMITED

发明人： Bhavesh DAVE ,  Rakesh Kumar BANERJEE ,  Samiron PHUKAN ,  Abhijit Datta KHOJE ,  Rajkumar HANGARGE ,  Jitendra Sambhaji JADHAV ,  Venkata P. PALLE ,  Rajender Kumar KAMBOJ

IPC分类号： C07D471/04 ,  A61K31/541 ,  A61K31/5377 ,  A61K45/06 ,  A61K31/519

CPC分类号： C07D471/04 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06 ,  A61N5/10

摘要： The present disclosure is related to heteroaryl compounds as MEK inhibitors. These compounds include heteroaryl compounds of formula I, their pharmaceutically acceptable salts, combinations with suitable medicament and pharmaceutical compositions thereof. The present disclosure also includes processes of preparation of the compounds and their use in methods of treatment. The compounds as disclosed herein are of Formula (I) below:

公开(公告)号：US20160331753A1

公开(公告)日：2016-11-17

申请号：US15218980

申请日：2016-07-25

申请人： LUPIN LIMITED

发明人： Bhavesh DAVE ,  Rakesh Kumar BANERJEE ,  Samiron PHUKAN ,  Abhijit Datta KHOJE ,  Rajkumar HANGARGE ,  Jitendra Sambhaji JADHAV ,  Venkata P. PALLE ,  Rajender Kumar KAMBOJ

IPC分类号： A61K31/519 ,  A61N5/10 ,  A61K31/541 ,  A61K45/06 ,  A61K31/5377

CPC分类号： C07D471/04 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06 ,  A61N5/10

摘要： The present disclosure is related to heteroaryl compounds as MEK inhibitors. These compounds include heteroaryl compounds of formula I, their pharmaceutically acceptable salts, combinations with suitable medicament and pharmaceutical compositions thereof. The present disclosure also includes processes of preparation of the compounds and their use in methods of treatment. The compounds as disclosed herein are of Formula (I) below: