公开(公告)号：US20180186777A1

公开(公告)日：2018-07-05

申请号：US15757103

申请日：2016-09-03

申请人： LUPIN LIMITED

发明人： Vidya RAMDAS ,  Rajeshkumar Maganlal LORIYA ,  Moloy BANERJEE ,  Pradeep Rangrao PATIL ,  Advait Arun JOSHI ,  Laxmikant Shamlal DATRANGE ,  Deepak Sahebrao WALKE ,  Talha Hussain KHAN ,  Amit Kumar DAS ,  Ganesh Navinchandra GOTE ,  Vaibhav Madhukar KALHAPURE ,  Venkata P. PALLE ,  Rajender Kumar KAMBOJ

IPC分类号： C07D405/12 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  A61P29/00

CPC分类号： C07D405/12 ,  A61P29/00 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14

摘要： The present invention relates to sulfonamide compounds Formula (I) wherein the substituents are as described herein, and their use in a medicine for the treatment of diseases, disorders associated with the inhibition of Voltage-gated sodium channels (VGSC) particularly NaV1.7. It further relates to the compounds herein and their pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof useful in treating diseases, disorders, syndromes and/or conditions associated with the inhibition of Voltage-gated sodium channels (VGSC) particularly NaV1.7. The invention also relates to process for the preparation of the compounds of the invention.

公开(公告)号：US20220144852A1

公开(公告)日：2022-05-12

申请号：US17598524

申请日：2020-03-21

申请人： LUPIN LIMITED

发明人： Navnath Popat KARCHE ,  Moloy BANERJEE ,  Pradeep Rangrao PATIL ,  Vinod Popatrao VYAVAHARE ,  Deepak Sahebrao WALKE ,  Vaibhav Madhukar KALHAPURE ,  Vidya RAMDAS ,  Venkata P. PALLE ,  Rajender Kumar KAMBOJ

IPC分类号： C07D498/16

摘要： Disclosed are the macrocyclic compounds having the general Formula (I) and their tautomeric forms, stereoisomers, pharmaceutically acceptable salts, and their combination with suitable medicament, corresponding processes for the synthesis and pharmaceutical compositions and uses of compounds disclosed herein.