公开(公告)号：US5250297A

公开(公告)日：1993-10-05

申请号：US939384

申请日：1992-08-31

Applicant: Lana S. Grauer ,  Julia P. Leung ,  Barry S. Wilson

Inventor： Lana S. Grauer ,  Julia P. Leung ,  Barry S. Wilson

IPC: A61K38/00 ,  C07K14/47 ,  C07K16/30 ,  A61K39/00 ,  C07K15/00

CPC classification number: C07K14/4748 ,  C07K16/3023 ,  A61K38/00

Abstract: A novel tumor-associated antigen expressed by lung adenocarcinoma is disclosed. The antigen, characterized by monoclonal antibody LA20207, has a molecular weight in the range of about 50,000 to about 80,000 daltons and an isoelectric point in the range of about 4.9 to about 6.5. Antibodies directed against the antigen, methods for their production and diagnostic and therapeutic uses therefor are also provided.

Abstract translation: 公开了一种由肺腺癌表达的新型肿瘤相关抗原。 以单克隆抗体LA20207为特征的抗原具有约50,000至约80,000道尔顿范围内的分子量和约4.9至约6.5范围内的等电点。 还提供针对抗原的抗体，其制备方法及其诊断和治疗用途。