公开(公告)号：US4662884A

公开(公告)日：1987-05-05

申请号：US603835

申请日：1984-04-25

申请人： Larry J. Stensaas ,  R. Joseph Todd ,  Philip M. Triolo

发明人： Larry J. Stensaas ,  R. Joseph Todd ,  Philip M. Triolo

IPC分类号： A61B17/11 ,  A61F2/00 ,  A61F2/04

CPC分类号： A61F2/04 ,  A61B17/1128 ,  A61F2002/30235 ,  A61F2230/0069

摘要： The present invention is directed to prostheses and methods for promoting nerve regeneration. The proximal and distal ends of a severed nerve are brought into close proximity and are enclosed by a tubular prosthesis. In one preferred embodiment, a monosuture is used to hold the nerve ends in close proximity. A tight seal is formed between the prosthesis and the injured nerve so as to isolate the injured nerve within the prosthesis from the rest of the body of the host. Additionally, in one preferred embodiment, nerve grafts may be incorporated into the prosthesis and nerve regeneration promoting substances may be incorporated within the nerve graft to further enhance nerve regeneration. Prostheses and methods for inhibiting the formation of neuromas are also disclosed.

摘要翻译： 本发明涉及用于促进神经再生的假体和方法。 切断的神经的近端和远端紧密接近，并被管状假体包围。 在一个优选实施例中，使用单缝来保持紧邻的神经末端。 在假体和受损的神经之间形成紧密的密封，以将假体中的受伤神经与主体的其余部分分离。 此外，在一个优选实施例中，神经移植物可以并入假体中，并且可以将神经再生促进物质并入神经移植物内以进一步增强神经再生。 还公开了抑制神经瘤形成的假体和方法。

公开(公告)号：US4778467A

公开(公告)日：1988-10-18

申请号：US884088

申请日：1986-07-10

申请人： Larry J. Stensaas ,  R. Joseph Todd ,  Philip M. Triolo

发明人： Larry J. Stensaas ,  R. Joseph Todd ,  Philip M. Triolo

IPC分类号： A61B17/11 ,  A61F2/00 ,  A61F2/04

CPC分类号： A61F2/04 ,  A61B17/1128 ,  A61F2002/30235 ,  A61F2230/0069

摘要： The present invention is directed to prosthesis and methods for promoting nerve regeneration. The proximal and distal ends of a severed nerve are brought into close proximity and are enclosed by a tubular prosthesis. In one preferred embodiment, a epineurial or endoneurial monosuture is used to hold the nerve ends in close proximity. A tight seal is formed between the prosthesis and the injured nerve so as to isolate the injured nerve within the prosthesis from the rest of the body of the host. Additionally, in one preferred embodiment, nerve grafts may be incorporated into the prosthesis and nerve regeneration promoting substances may be incorporated within the nerve graft to further enhance nerve regeneration. In another preferred embodiment, a prosthesis is coated with a material which is slippery with relation to the surrounding body tissue and the prosthesis is formed of or coated with a material around the inside of the prosthesis which will substantially adhere to the severed nerve ends so as to prevent substantial movement of the severed nerve ends within the prosthesis. In yet another preferred embodiment, such an outside coating around the prosthesis terminates in two longitudinal flaps which serve to form a fluid-tight seal along the tubular prosthesis. In still another preferred embodiment, the ends of the prosthesis overlap and are formed so as to bias against each other in a spiral tube configuration, thereby providing for firm closure of the prosthesis around a variety of sizes of injured nerves. Also disclosed are various devices and methods for inhibiting the formation of neuromas, such as an open-ended tube or a neuroma-inhibition device formed as a cap member having a reservoir formed therein.

摘要翻译： 本发明涉及用于促进神经再生的假体和方法。 切断的神经的近端和远端紧密接近，并被管状假体包围。 在一个优选实施例中，使用神经节或内膜单节使得紧密接近的神经末端。 在假体和受损的神经之间形成紧密的密封，以将假体中的受伤神经与主体的其余部分分离。 此外，在一个优选实施例中，神经移植物可以并入假体中，并且可以将神经再生促进物质并入神经移植物内以进一步增强神经再生。 在另一个优选实施例中，假体用相对于周围身体组织滑动的材料涂覆，并且假体由假体附近的材料形成或涂覆，该材料将基本上粘附到切断的神经末端，以便 以防止假体中切断的神经末梢的实质运动。 在另一个优选实施例中，假体周围的这种外部涂层终止于两个纵向翼片，其用于沿着管状假体形成流体密封的密封。 在另一优选实施例中，假体的端部重叠并形成为以螺旋管构造彼此偏压，从而提供围绕各种尺寸的受伤神经的假体的牢固关闭。 还公开了用于抑制神经瘤形成的各种装置和方法，例如形成为具有在其中形成的储液器的盖构件的开口管或神经阻滞装置。