公开(公告)号：US20130131096A1

公开(公告)日：2013-05-23

申请号：US13696541

申请日：2011-05-06

申请人： Laszlo Puskas ,  Csaba Szabo ,  Ivan Kanizsai ,  Mario Gyuris ,  Ramona Madacsi ,  Bela Ozsvari ,  Liliana Feher ,  Gabor Tamas

发明人： Laszlo Puskas ,  Csaba Szabo ,  Ivan Kanizsai ,  Mario Gyuris ,  Ramona Madacsi ,  Bela Ozsvari ,  Liliana Feher ,  Gabor Tamas

IPC分类号： C07D413/12 ,  C07D401/14 ,  C07D401/10 ,  C07D401/12 ,  C07D215/26

CPC分类号： C07D413/12 ,  C07D215/26 ,  C07D401/06 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14

摘要： The invention relates to compounds of the general formula (I) and their pharmaceutically acceptable salts (in which formula R1 represents a hydrogen atom, lower alkyl group, lower alkenyl group, lower cycloalkyl group, aryl group, aralkyl group or heterocyclic group, wherein, the above groups are optionally substituted in ortho, meta and/or para position with 1, 2, 3 or 4 electron withdrawing groups or electron donating groups; R2 represents a hydrogen atom, lower alkyl group, aryl group, aralkyl group or heterocyclic group wherein the above groups are optionally substituted with one or more halogen atoms; R3 represents a lower alkyl group, aryl group, aralkyl group or heterocyclic group wherein the above groups are optionally substituted in ortho, meta or para position with 1, 2, 3 or 4 electron withdrawing groups or electron donating groups; R4 represents a hydrogen atom, lower alkyl group or any acidic functional group; n is 1 or 2). The compounds according to the invention can be used in the medicine mainly for the treatment of diseases associated with neurological and/or oxidative stress.

摘要翻译： 本发明涉及通式（I）的化合物及其药学上可接受的盐（式中R1表示氢原子，低级烷基，低级烯基，低级环烷基，芳基，芳烷基或杂环基，其中， 上述基团任选在邻位，间位和/或对位用1,2,3或4个吸电子基团或给电子基团取代; R 2表示氢原子，低级烷基，芳基，芳烷基或杂环基，其中 上述基团任选被一个或多个卤素原子取代; R 3表示低级烷基，芳基，芳烷基或杂环基，其中上述基团在邻位，间位或对位任选被取代1,2,3或4 吸电子基团或给电子基团; R 4表示氢原子，低级烷基或任何酸性官能团; n为1或2）。 根据本发明的化合物可用于药物中，主要用于治疗与神经和/或氧化应激有关的疾病。

公开(公告)号：US08871937B2

公开(公告)日：2014-10-28

申请号：US13696541

申请日：2011-05-06

申请人： Laszlo Puskas ,  Csaba Szabo ,  Ivan Kanizsai ,  Mario Gyuris ,  Ramona Madacsi ,  Bela Ozsvari ,  Liliana Feher ,  Gabor Tamas

发明人： Laszlo Puskas ,  Csaba Szabo ,  Ivan Kanizsai ,  Mario Gyuris ,  Ramona Madacsi ,  Bela Ozsvari ,  Liliana Feher ,  Gabor Tamas

IPC分类号： C07D215/38 ,  C07D401/10 ,  C07D401/06 ,  C07D401/14 ,  C07D413/12 ,  C07D401/12 ,  C07D215/26

CPC分类号： C07D413/12 ,  C07D215/26 ,  C07D401/06 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14

摘要： The invention relates to compounds of the general formula (I) and their pharmaceutically acceptable salts (in which formula R1 represents a hydrogen atom, lower alkyl group, lower alkenyl group, lower cycloalkyl group, aryl group, aralkyl group or heterocyclic group, wherein, the above groups are optionally substituted in ortho, meta and/or para position with 1, 2, 3 or 4 electron withdrawing groups or electron donating groups; R2 represents a hydrogen atom, lower alkyl group, aryl group, aralkyl group or heterocyclic group wherein the above groups are optionally substituted with one or more halogen atoms; R3 represents a lower alkyl group, aryl group, aralkyl group or heterocyclic group wherein the above groups are optionally substituted in ortho, meta or para position with 1, 2, 3 or 4 electron withdrawing groups or electron donating groups; R4 represents a hydrogen atom, lower alkyl group or any acidic functional group; n is 1 or 2). The compounds according to the invention can be used in the medicine mainly for the treatment of diseases associated with neurological and/or oxidative stress.

摘要翻译： 本发明涉及通式（I）的化合物及其药学上可接受的盐（式中R1表示氢原子，低级烷基，低级烯基，低级环烷基，芳基，芳烷基或杂环基，其中， 上述基团任选在邻位，间位和/或对位用1,2,3或4个吸电子基团或给电子基团取代; R 2表示氢原子，低级烷基，芳基，芳烷基或杂环基，其中 上述基团任选被一个或多个卤素原子取代; R 3表示低级烷基，芳基，芳烷基或杂环基，其中上述基团在邻位，间位或对位任选被取代1,2,3或4 吸电子基团或给电子基团; R 4表示氢原子，低级烷基或任何酸性官能团; n为1或2）。 根据本发明的化合物可用于药物中，主要用于治疗与神经和/或氧化应激有关的疾病。