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公开(公告)号：US20100298413A1
公开(公告)日：2010-11-25
申请号：US12596005
申请日：2008-03-25
申请人： Laura Ferro , Massimo Iacobelli , Cinara Echart
发明人： Laura Ferro , Massimo Iacobelli , Cinara Echart
IPC分类号： A61K31/711 , A61P13/00 , A61P13/12
CPC分类号： A61K31/7088 , A61K31/711
摘要： The present study has demonstrated that heparanase expression and activity was increased in human microvascular endothelial cells and rat kidney epithelial cells growing under hyperglycemia condition, as found in diabetic nephropathy disease. Oligotide was able to: —downregulate the heparanase gene expression; —downregulate the cell surface protein expression; —decrease the heparanase enzymatic activity. Since heparanase is a critical factor in maintaining glomerular basement membrane integrity and is elevated in renal diseases, as for instance diabetic nephropathies. Oligotide should be considered for the management of these diseases.
摘要翻译： 本研究已经证明，在糖尿病肾病中发现，在高血糖状态下生长的人微血管内皮细胞和大鼠肾上皮细胞中肝素酶的表达和活性增加。 寡肽能够：下调肝素酶基因表达; 下调细胞表面蛋白表达; - 降低肝素酶的酶活性。 由于乙酰肝素酶是维持肾小球基底膜完整性的关键因素，并且在肾脏疾病中升高，例如糖尿病性肾病。 应该考虑使用寡核苷酸来治疗这些疾病。
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公开(公告)号：US20090131362A1
公开(公告)日：2009-05-21
申请号：US12305219
申请日：2007-05-14
IPC分类号： A61K31/711
CPC分类号： A61K31/711
摘要： A study has been carried out to verify the effect of Defibrotide on the activity and expression of Heparanase enzyme on myeloma tumor cells (U266) and human microvascular endothelial cells (HMEC). The study has demonstrated that defibrotide can be effectively used for the manufacture of a medicament for the treatment of diseaseses which are positively affected by the inhibition of Heparanse and/or by the downregulation of Heparanse gene expression, such as diabetes.
摘要翻译： 已经进行了一项研究，以验证Defibrotide对肝素酶对骨髓瘤肿瘤细胞（U266）和人微血管内皮细胞（HMEC）的活性和表达的影响。 该研究已经证明，defibrotide可以有效地用于制备用于治疗受到肝素的抑制的积极影响和/或通过下调Heparanse基因表达如糖尿病的疾病的药物。
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