公开(公告)号：US20110150998A1

公开(公告)日：2011-06-23

申请号：US12644607

申请日：2009-12-22

申请人： Laura-Lee Farrell ,  Chad E. Johnson

发明人： Laura-Lee Farrell ,  Chad E. Johnson

IPC分类号： A61K9/14 ,  B29C41/04 ,  A61P17/02

CPC分类号： A61K9/0087 ,  A61K38/39 ,  A61L27/3633 ,  A61L31/005 ,  B29C39/08 ,  B29C67/20

摘要： A method for forming an extracellular matrix material (ECM) material includes providing at least an ECM composition containing ECM particles varying in their capacity for migration through a fluid medium, including at least one population of expanded ECM particles. The ECM composition is combined in a fluid medium to form a flowable ECM composition. The flowable ECM composition is subjected to a centrifugal force in a mold for a period of time sufficient to distribute the ECM particles according to differences in their physical characteristics. The ECM composition is dried to form a dried ECM material having a density gradient extending from a less dense region to a more dense region. The dried ECM material may formed as a porous, substantially acellular ECM material expandable in an aqueous fluid environment by at least 100% in volume.

摘要翻译： 用于形成细胞外基质材料（ECM）材料的方法包括提供至少一种含有ECM颗粒的ECM组合物，其中ECM颗粒的能力通过流体介质（包括至少一个扩展的ECM颗粒群体）迁移。 ECM组合物在流体介质中组合以形成可流动的ECM组合物。 可流动的ECM组合物在模具中经受足够的离心力足以根据它们的物理特性的差异分布ECM颗粒。 将ECM组合物干燥以形成具有从较不密集区域延伸至更致密区域的密度梯度的干燥的ECM材料。 干燥的ECM材料可以形成为在水性流体环境中可膨胀至少100体积的多孔，基本上无细胞的ECM材料。

公开(公告)号：US08329219B2

公开(公告)日：2012-12-11

申请号：US12644607

申请日：2009-12-22

申请人： Laura-Lee Farrell ,  Chad E. Johnson

发明人： Laura-Lee Farrell ,  Chad E. Johnson

IPC分类号： A61K9/14 ,  B29C41/04 ,  A61P17/02

CPC分类号： A61K9/0087 ,  A61K38/39 ,  A61L27/3633 ,  A61L31/005 ,  B29C39/08 ,  B29C67/20

摘要： A method for forming an extracellular matrix material (ECM) material includes providing at least an ECM composition containing ECM particles varying in their capacity for migration through a fluid medium, including at least one population of expanded ECM particles. The ECM composition is combined in a fluid medium to form a flowable ECM composition. The flowable ECM composition is subjected to a centrifugal force in a mold for a period of time sufficient to distribute the ECM particles according to differences in their physical characteristics. The ECM composition is dried to form a dried ECM material having a density gradient extending from a less dense region to a more dense region. The dried ECM material may formed as a porous, substantially acellular ECM material expandable in an aqueous fluid environment by at least 100% in volume.

摘要翻译： 用于形成细胞外基质材料（ECM）材料的方法包括提供至少一种含有ECM颗粒的ECM组合物，其中ECM颗粒的能力通过流体介质（包括至少一个扩展的ECM颗粒群体）迁移。 ECM组合物在流体介质中组合以形成可流动的ECM组合物。 可流动的ECM组合物在模具中经受足够的离心力足以根据其物理特性的差异分布ECM颗粒。 将ECM组合物干燥以形成具有从较不密集区域延伸至更致密区域的密度梯度的干燥的ECM材料。 干燥的ECM材料可以形成为在水性流体环境中可膨胀至少100体积的多孔，基本上无细胞的ECM材料。