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公开(公告)号：US20120329795A1
公开(公告)日：2012-12-27
申请号：US13607999
申请日：2012-09-10
IPC分类号： A61K31/517 , A61P35/00 , A61K31/5377
CPC分类号： C04B35/632 , C07D401/12
摘要： The invention concerns quinazoline derivatives of Formula I: wherein each of R1, X1, R2, R3, R5, n and m have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours which are sensitive to inhibition of EGF and erbB receptor tyrosine kinases.
摘要翻译： 本发明涉及式I的喹唑啉衍生物：其中R1，X1，R2，R3，R5，n和m各自具有本说明书中定义的任何含义; 其制备方法，含有它们的药物组合物及其在制备用于预防或治疗对EGF和erbB受体酪氨酸激酶的抑制敏感的肿瘤中作为抗增殖剂的药物中的用途。
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公开(公告)号：US20080096881A1
公开(公告)日：2008-04-24
申请号：US10571991
申请日：2004-09-15
IPC分类号： A61K31/517 , A61K31/496 , A61K31/5377 , A61P35/00 , C07D401/12 , C07D401/14 , C07D413/14
CPC分类号： C04B35/632 , C07D401/12
摘要： The invention concerns quinazoline derivatives of Formula (I): wherein each of R1, X1, R2, R3, R5, n and m have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours which are sensitive to inhibition of EGF and erbB receptor tyrosine kinases.
摘要翻译： 本发明涉及式（I）的喹唑啉衍生物：其中R 1，X 1，R 2，R 3， R 5，n和m具有本说明书中定义的任何含义; 其制备方法，含有它们的药物组合物及其在制备用于预防或治疗对EGF和erbB受体酪氨酸激酶的抑制敏感的肿瘤中作为抗增殖剂的药物中的用途。
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公开(公告)号：US20110237610A1
公开(公告)日：2011-09-29
申请号：US12902543
申请日：2010-10-12
IPC分类号： A61K31/517 , C07D409/14 , C07D413/14 , C07D401/12 , C07D401/14 , A61P35/00
CPC分类号： C07D413/14 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14
摘要： The invention concerns quinazoline derivatives of Formula I wherein each of R1a, R1b, R2, R3 and a have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours which are sensitive to inhibition of erbB receptor tyrosine kinases.
摘要翻译： 本发明涉及式I的喹唑啉衍生物，其中R1a，R1b，R2，R3和a各自具有本说明书中定义的任何含义; 其制备方法，含有它们的药物组合物及其在制备用于预防或治疗对erbB受体酪氨酸激酶抑制敏感的肿瘤中的抗增殖剂的药物中的用途。
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公开(公告)号：US07838530B2
公开(公告)日：2010-11-23
申请号：US10572794
申请日：2004-09-22
IPC分类号： A61K31/517 , C07D239/72
CPC分类号： C07D413/14 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14
摘要： The invention concerns quinazoline derivatives of Formula (I), wherein each of R1a, R1b, R2, R3 and a have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours which are sensitive to inhibition of erbB receptor tyrosine kinases.
摘要翻译： 本发明涉及式（I）的喹唑啉衍生物，其中R1a，R1b，R2，R3和a各自具有本说明书中定义的任何含义; 其制备方法，含有它们的药物组合物及其在制备用于预防或治疗对erbB受体酪氨酸激酶抑制敏感的肿瘤中的抗增殖剂的药物中的用途。
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公开(公告)号：US20100152442A1
公开(公告)日：2010-06-17
申请号：US12706675
申请日：2010-02-16
IPC分类号： C07D413/14 , C07D403/12
CPC分类号： C07D401/12 , C07D403/12
摘要： The invention concerns quinazoline derivatives of Formula (I) wherein each of Q1, Z, R1 and Q2 have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours which are sensitive to inhibition of erbB receptor tyrosine kinases.
摘要翻译： 本发明涉及式（I）的喹唑啉衍生物，其中Q1，Z，R1和Q2各自具有在说明书中定义的任何含义; 其制备方法，含有它们的药物组合物及其在制备用于预防或治疗对erbB受体酪氨酸激酶抑制敏感的肿瘤中的抗增殖剂的药物中的用途。
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公开(公告)号：US07148230B2
公开(公告)日：2006-12-12
申请号：US10857342
申请日：2004-06-01
申请人： Robert Hugh Bradbury , Jason Grant Kettle , James McCabe , Andrew Turner , Laurent Francois Andre Hennequin
发明人： Robert Hugh Bradbury , Jason Grant Kettle , James McCabe , Andrew Turner , Laurent Francois Andre Hennequin
IPC分类号： A61K31/517 , C07D43/02
CPC分类号： C07D401/12
摘要： The invention concerns quinazoline derivatives of Formula I wherein R1 and R2 have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours which are sensitive to inhibition of erbB, particularly EGF, receptor tyrosine kinases.
摘要翻译： 本发明涉及式I的喹唑啉衍生物，其中R 1和R 2具有本说明书中定义的任何含义; 其制备方法，含有它们的药物组合物及其在制备用于预防或治疗对抑制erbB，特别是EGF，受体酪氨酸激酶敏感的肿瘤中的抗增殖剂的药物中的用途。
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公开(公告)号：US08399667B2
公开(公告)日：2013-03-19
申请号：US12706675
申请日：2010-02-16
IPC分类号： C07D239/72
CPC分类号： C07D401/12 , C07D403/12
摘要： The invention concerns quinazoline derivatives of Formula (I) wherein each of Q1, Z, R1 and Q2 have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours which are sensitive to inhibition of erbB receptor tyrosine kinases.
摘要翻译： 本发明涉及式（I）的喹唑啉衍生物，其中Q1，Z，R1和Q2各自具有在说明书中定义的任何含义; 其制备方法，含有它们的药物组合物及其在制备用于预防或治疗对erbB受体酪氨酸激酶抑制敏感的肿瘤中的抗增殖剂的药物中的用途。
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公开(公告)号：US07625908B2
公开(公告)日：2009-12-01
申请号：US10578663
申请日：2004-11-11
IPC分类号： A61K31/517 , A61P35/02 , C07D239/84 , A61K31/4965
CPC分类号： C07D401/14 , C04B35/632 , C07D239/94 , C07D401/12 , C07D403/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12
摘要： A quinazoline derivative of the Formula (I): wherein the substituents are as defined in the text for use in the production of an anti proliferative effect which effect is produced alone or in part by inhibiting erbB2 receptor tyrosine kinase in a warm-blooded animal such as man.
摘要翻译： 式（I）的喹唑啉衍生物：其中取代基如用于产生抗增殖作用的文本中所定义，其作用单独或部分通过在温血动物中抑制erbB2受体酪氨酸激酶而产生， 作为人
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公开(公告)号：US20080269487A1
公开(公告)日：2008-10-30
申请号：US12147250
申请日：2008-06-26
IPC分类号： C07D401/02
CPC分类号： C07D401/12 , C07D403/12
摘要： The invention concerns quinazoline derivatives of Formula (I) wherein each of Q1, Z, R1 and Q2 have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours which are sensitive to inhibition of erbB receptor tyrosine kinases.
摘要翻译： 本发明涉及式（I）的喹唑啉衍生物，其中Q 1，Z，R 1和Q 2 2中的每一个具有定义的任何含义 在说明中; 其制备方法，含有它们的药物组合物及其在制备用于预防或治疗对erbB受体酪氨酸激酶抑制敏感的肿瘤中的抗增殖剂的药物中的用途。
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公开(公告)号：US07173136B2
公开(公告)日：2007-02-06
申请号：US10532958
申请日：2003-10-28
IPC分类号： C07D215/38 , C07D215/44
CPC分类号： C07D405/12
摘要： The invention concerns quinoline derivatives of Formula (I) wherein each of Z1, m, R1, n, R3, Z2 and R14 have any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an anti-invasive or anti-proliferative agent in the containment and/or treatment of solid tumour disease
摘要翻译： 本发明涉及式（I）的喹啉衍生物，其中Z 1，m，R 1，n，R 3，Z， > 2 和R 14具有上文在说明书中定义的任何含义; 其制备方法，含有它们的药物组合物及其在制备用作在实体瘤疾病的遏制和/或治疗中的抗侵袭或抗增殖剂的药物中的用途
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