专利检索 ap:("Laurent Ingrassia" OR "Lise Wlodarczak" OR "Stephanie Thomas" OR "Eric Van Quaquebeke" OR "Laurent Van den Hove" OR "Robert Kiss" OR "Francis Darro") AND inv:"Lise Wlodarczak" 第 1 页

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发明申请
ISOCARBOSTYRIL ALKALOID DERIVATIVES HAVING ANTI-PROLIFERATIVE AND ANTI-MIGRATORY ACTIVITIES 审中-公开
标题翻译：具有抗增生活性和抗活性活性的异烟碱碱性阿片碱衍生物

公开(公告)号：US20100076005A1

公开(公告)日：2010-03-25

申请号：US12445405

申请日：2007-10-12

申请人： Laurent Ingrassia , Lise Wlodarczak , Stephanie Thomas , Eric Van Quaquebeke , Laurent Van den Hove , Robert Kiss , Francis Darro

发明人： Laurent Ingrassia , Lise Wlodarczak , Stephanie Thomas , Eric Van Quaquebeke , Laurent Van den Hove , Robert Kiss , Francis Darro

IPC分类号： A61K31/4355 , C07D491/02 , A61P35/04

CPC分类号： C07D491/06

摘要： Isocarbostyril alkaloid derivatives having an anti-proliferative and anti-migratory activities are disclosed. In particular, compounds of formula (I) or (II), as well as stereoisomers, tautomers, racemates, prodrugs, metabolites thereof, pharmaceutically acceptable salt and/or solvate are encompassed which are useful in the treatment and prophylaxis of cancer. Methods of preparation are also disclosed.

摘要翻译： 公开了具有抗增殖和抗迁移活性的异卡波斯特尔生物碱衍生物。特别地，包括可用于治疗和预防癌症的式（I）或（II）的化合物以及立体异构体，互变异构体，外消旋体，前药，其代谢物，药学上可接受的盐和/或溶剂合物。还公开了制备方法。