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1.发明授权1-(4'-alkylamido)-2 '{1[n-(alkyl)imino]-ethyl}-phenoxy-3-alkylamino-2-propanols and use thereof 失效1-（4'-烷基酰氨基）-2'{1 [正（烷基）亚氨基] - 乙基} - 苯氧基-3-烷基氨基-2-丙醇及其用途
公开(公告)号：US4579970A
公开(公告)日：1986-04-01
申请号：US622224
申请日：1984-06-19
IPC分类号： C07D317/22 , C07C103/38
CPC分类号： C07D317/22
摘要： The present invention concerns new (R)-, (S)- and (R,S)-1-(4'-alkylamido)-2'-{1-[N-(alkyl)imino]ethyl}phenoxy-3-alklyamino-2-propanols having the general formula ##STR1## wherein R means a straight or branched C.sub.1 -C.sub.4 -alkyl group, especially the n-propyl group, and R.sub.1 means hydrogen or a straight or branched C.sub.1 -C.sub.4 -alkyl group, especially the isopropyl group, which compounds are useful intermediates when preparing the pharmacologically active (R)-, (S)- and (R,S)-1-(4'-alkylamido-2'-acetyl)phenoxy-3-alkylamino-2-propanols of the formula ##STR2## wherein R and R.sub.1 have the meaning given above.
摘要翻译： 本发明涉及新的（R） - ，（S） - 和（R，S）-1-（4'-烷基酰胺基）-2' - {1- [N-（烷基）亚氨基]乙基}苯氧基-3- 具有通式为“IX”的烷基酰胺-2-丙醇其中R表示直链或支链C 1 -C 4 - 烷基，特别是正丙基，R 1表示氢或直链或支链C 1 -C 4 - 烷基 （R） - ，（S） - 和（R，S）-1-（4'-烷基酰氨基-2'-乙酰基）苯氧基-3-烷基氨基（特别是异丙基），该化合物在制备药理活性 -2-丙醇，其中R和R 1具有上面给出的含义。
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公开(公告)号：US4169840A
公开(公告)日：1979-10-02
申请号：US850868
申请日：1977-11-14
IPC分类号： A61K31/37 , C07D311/16 , C07D493/04
CPC分类号： C07D493/04 , C07D311/16
摘要： This invention relates to an improved method of preparing furocoumarins having the following formula: ##STR1## wherein R is a radical selected from the group consisting of hydrogen, hydroxy and lower alkoxy, which comprises reacting a coumarin having the following formula: ##STR2## or the alkali metal salt thereof, with a haloacetal having the following formula: ##STR3## WHEREIN R.sub.1 is a lower alkyl group and Hal is selected from the group consisting of chlorine and bromine; and to the intermediate products thereof, namely a substituted coumarin acetal of the following formula: ##STR4## and the corresponding coumarin aldehyde of the following formula: ##STR5##
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