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公开(公告)号：US06723518B2
公开(公告)日：2004-04-20
申请号：US09834795
申请日：2001-04-13
IPC分类号： G01N3353
CPC分类号： C07K14/523 , A61K39/00 , Y10S530/832
摘要： An isolated chemokine is disclosed. The isolated chemokine is expressed preferentially in breast tissue or can be detected in breast milk. It includes from about 100 to about 132 amino acids, has a deduced molecular weight of from about 10 to about 16 kDa, and has a deduced isoionic point of from about pH 10.1 to about pH 10.7. Antibodies and binding portions thereof recognizing the subject chemokine and peptides which include the antigenic portions of the subject chemokines are described. DNA molecules which encode the subject chemokines as well as nucleic acid molecules which, under stringent conditions, hybridize to nucleic acid molecules encoding the subject chemokines or to a complement thereof are also disclosed. The chemokines, peptides, antibodies and binding portions thereof, and nucleic acid molecules can be used to detect and treat breast disease, such as inflammations, infections, mastitis, benign cystitis, benign hyperplasias, cancer and other malignancies as well as other pathological states of the mammary gland.
摘要翻译： 公开了一种分离的趋化因子。 分离的趋化因子优先在乳腺组织中表达或可以在母乳中检测到。 其包括约100至约132个氨基酸，具有约10至约16kDa的推测分子量，并且具有约pH 10.1至约pH 10.7的推导的等离子点。 描述了识别主题趋化因子的抗体及其结合部分和包括受试者趋化因子的抗原部分的肽。 还公开了编码主题趋化因子的DNA分子以及在严格条件下与编码主题趋化因子或其互补序列的核酸分子杂交的核酸分子。 趋化因子，肽，抗体及其结合部分和核酸分子可用于检测和治疗乳腺疾病，如炎症，感染，乳腺炎，良性膀胱炎，良性增生，癌症和其他恶性肿瘤以及其他病理状态 乳腺。
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公开(公告)号：US06306653B1
公开(公告)日：2001-10-23
申请号：US09146580
申请日：1998-09-03
IPC分类号： C12N512
CPC分类号： C07K14/523 , A61K39/00 , Y10S530/832
摘要： An isolated chemokine is disclosed. The isolated chemokine is expressed preferentially in breast tissue or can be detected in breast milk. It includes from about 100 to about 132 amino acids, has a deduced molecular weight of from about 10 to about 16 kDa, and has a deduced isoionic point of from about pH 10.1 to about pH 10.7. Antibodies and binding portions thereof recognizing the subject chemokine and peptides which include the antigenic portions of the subject chemokines are described. DNA molecules which encode the subject chemokines as well as nucleic acid molecules which, under stringent conditions, hybridize to nucleic acid molecules encoding the subject chemokines or to a complement thereof are also disclosed. The chemokines, peptides, antibodies and binding portions thereof, and nucleic acid molecules can be used to detect and treat breast disease, such as inflammations, infections, mastitis, benign cystitis, benign hyperplasias, cancer and other malignancies as well as other pathological states of the mammary gland.
摘要翻译： 公开了一种分离的趋化因子。 分离的趋化因子优先在乳腺组织中表达或可以在母乳中检测到。 其包括约100至约132个氨基酸，具有约10至约16kDa的推测分子量，并且具有约pH 10.1至约pH 10.7的推导的等离子点。 描述了识别主题趋化因子的抗体及其结合部分和包括受试者趋化因子的抗原部分的肽。 还公开了编码主题趋化因子的DNA分子以及在严格条件下与编码主题趋化因子或其互补序列的核酸分子杂交的核酸分子。 趋化因子，肽，抗体及其结合部分和核酸分子可用于检测和治疗乳腺疾病，如炎症，感染，乳腺炎，良性膀胱炎，良性增生，癌症和其他恶性肿瘤以及其他病理状态 乳腺。
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