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公开(公告)号：US20220339291A1
公开(公告)日：2022-10-27
申请号：US16964965
申请日：2020-03-05
发明人： Chang Sik Park , Min Ji Choi , Tae Ik Jang , Yun-Hee Park , Ho Young Song , Ju Yuel Baek , Sung Min Kim , Hyeun Joung Lee , Ju Young Lee , Hyoung Rae Kim , Kun Jung Lee , Yong Zu Kim , Chang Sun Lee , Jeiwook Chae , Sang Pil Lee , Ji-Young Shin , Sunha Yoon , Yunseon Choi , Jae Eun Park , Jisu Lee , Bum-Chan Park , Young Woo Park
摘要： The present invention relates to new antibody-drug conjugates (ADCs) targeting DLK1, active metabolites of such ADCs, methods for preparation of such ADCs, uses for such ADCs in treatment and/or prevention of illnesses, and uses for such ADCs in production of drugs for treatment and/or prevention of diseases, more specifically, uses for such ADCs in producing drugs for treatment and/or prevention of proliferative and/or angiogenetic diseases, for example, cancer. More particularly, the present invention relates to an antibody-drug conjugate comprising an antibody binding with DLK1 or an antigen-binding fragment thereof, and a pharmaceutical composition comprising the same.
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公开(公告)号：US11306141B2
公开(公告)日：2022-04-19
申请号：US16644764
申请日：2018-09-10
申请人： Y-BIOLOGICS INC.
发明人： Jung Chae Lim , Ji-Young Shin , Sunha Yoon , Sang Pil Lee , Yunseon Choi , Jisu Lee , Young-Gyu Cho , Seok Ho Yoo , Yeung chul Kim , Si Hyung Lee , Jae Eun Park , Youngja Song , Gi Sun Baek , Bum-chan Park , Young Woo Park
IPC分类号： C07K16/28 , A61K47/68 , A61P35/00 , C07K14/705
摘要： The present invention relates to an antibody against delta-like 1 homolog (Drosophila) (DLK1) or an antigen-binding fragment thereof, a nucleic acid encoding the same, a vector comprising the nucleic acid, a cell transformed with the vector, a method for producing the antibody or an antigen-binding fragment thereof, an antibody drug conjugate (ADC) comprising the same, a pharmaceutical composition for treating cancer, a composition for diagnosing cancer, and a chimeric antigen receptor (CAR) and a T-cell engager comprising the same.
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公开(公告)号：US20210214432A1
公开(公告)日：2021-07-15
申请号：US16644764
申请日：2018-09-10
申请人： Y-BIOLOGICS INC.
发明人： Jung Chae Lim , Ji-Young Shin , Sunha Yoon , Sang Pil Lee , Yunseon Choi , Jisu Lee , Young-Gyu Cho , Seok Ho Yoo , Yeung chul Kim , Si Hyung Lee , Jae Eun Park , Youngja Song , Gi Sun Baek , Bum-chan Park , Young Woo Park
IPC分类号： C07K16/28 , A61K47/68 , C07K14/705 , A61P35/00
摘要： The present invention relates to an antibody against delta-like 1 homolog (Drosophila) (DLK1) or an antigen-binding fragment thereof, a nucleic acid encoding the same, a vector comprising the nucleic acid, a cell transformed with the vector, a method for producing the antibody or an antigen-binding fragment thereof, an antibody drug conjugate (ADC) comprising the same, a pharmaceutical composition for treating cancer, a composition for diagnosing cancer, and a chimeric antigen receptor (CAR) and a T-cell engager comprising the same.
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公开(公告)号：US10919966B2
公开(公告)日：2021-02-16
申请号：US16321412
申请日：2017-08-07
申请人： Y-BIOLOGICS INC.
发明人： Jae Eun Park , Soo A Choi , Jisu Lee , Hyun Mi Lee , Si Hyung Lee , Gi Sun Baek , Yeung Chul Kim , Bum-chan Park , Jung Chae Lim , Young-Gyu Cho , Young Woo Park
摘要： Disclosed are an antibody to human programmed cell death-ligand 1 (PD-L1) or an antigen-binding fragment thereof, a nucleic acid encoding the same, a vector including the nucleic acid, a cell transformed with the vector, a method for producing the antibody or an antigen-binding fragment thereof, and a composition for preventing or treating cancer or infectious diseases containing the same.
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公开(公告)号：US20190322750A1
公开(公告)日：2019-10-24
申请号：US16321412
申请日：2017-08-07
申请人： Y-BIOLOGICS INC.
发明人： Jae Eun Park , Soo A Choi , Jisu Lee , Hyun Mi Lee , Si Hyung Lee , Gi Sun Baek , Yeung Chul Kim , Bum-chan Park , Jung Chae Lim , Young-Gyu Cho , Young Woo Park
IPC分类号： C07K16/28
摘要： Disclosed are an antibody to human programmed cell death-ligand 1 (PD-L1) or an antigen-binding fragment thereof, a nucleic acid encoding the same, a vector including the nucleic acid, a cell transformed with the vector, a method for producing the antibody or an antigen-binding fragment thereof, and a composition for preventing or treating cancer or infectious diseases containing the same.
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