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1.发明授权Use of herpesviruses, herpesvirus proteins and nucleic acids encoding the proteins to inhibit CCR5-tropic HIV-1 infection and replication 有权使用疱疹病毒，疱疹病毒蛋白和编码蛋白质的核酸来抑制CCR5-嗜性HIV-1感染和复制公开(公告)号：US07968298B2
公开(公告)日：2011-06-28
申请号：US10473560
申请日：2002-03-28
CPC分类号： A61K38/162 , A61K35/763 , A61K48/00 , C12N2710/16532
摘要： It has been discovered that herpesviruses can trigger an increase in the production of HIV-suppressive chemokines, and that these chemokines block the CCR5 receptor, which is used as a co-receptor with CD4 in the CCR5-tropic forms of HIV-1 that predominate in early stage HIV-1 infection. Use of live, attenuated or killed herpesviruses, or of herpesvirus proteins which trigger an increase in production of HIV-suppressive chemokines, or of nucleic acids encoding those proteins, can likewise be used to prevent establishment of HIV-1 infection or to inhibit HIV-1 replication. The invention provides uses, methods and compositions related to these discoveries.
摘要翻译： 已经发现，疱疹病毒可以引发HIV抑制趋化因子的产生增加，并且这些趋化因子阻断CCR5受体，其被用作HIV-1的CCR5-热带形式的CD4的共受体，其主要是 在早期HIV-1感染。 使用活的，减毒的或杀死的疱疹病毒，或引发HIV抑制趋化因子产生增加的疱疹病毒蛋白质，或编码这些蛋白质的核酸也可用于预防HIV-1感染的建立或抑制HIV- 1复制。 本发明提供了与这些发现相关的用途，方法和组合。
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2.发明申请Use of herpesviruses, herpesvirus proteins and nucleic acids encoding the proteins to inhibit ccr5-tropic hiv-1 infection and replication 有权使用疱疹病毒，疱疹病毒蛋白和编码蛋白质的核酸来抑制ccr5-嗜性Hiv-1感染和复制公开(公告)号：US20050123510A1
公开(公告)日：2005-06-09
申请号：US10473560
申请日：2002-03-28
IPC分类号： A61K35/76 , A61K35/763 , A61K38/16 , A61K48/00
CPC分类号： A61K38/162 , A61K35/763 , A61K48/00 , C12N2710/16532
摘要： It has been discovered that herpesviruses can trigger an increase in the production of HIV-suppressive chemokines, and that these chemokines block the CCR5 receptor, which is used as a co-receptor with CD4 in the CCR5-tropic forms of HIV-1 that predominate in early stage HIV-1 infection. Use of live, attenuated or killed herpesviruses, or of herpesvirus proteins which trigger an increase in production of HIV-suppressive chemokines, or of nucleic acids encoding those proteins, can likewise be used to prevent establishment of HIV-1 infection or to inhibit HIV-1 replication. The invention provides uses, methods and compositions related to these discoveries.
摘要翻译： 已经发现，疱疹病毒可以引发HIV抑制趋化因子的产生增加，并且这些趋化因子阻断CCR5受体，其被用作HIV-1的CCR5-热带形式的CD4的共受体，其主要是 在早期HIV-1感染。 使用活的，减毒的或杀死的疱疹病毒，或引发HIV抑制趋化因子产生增加的疱疹病毒蛋白质，或编码这些蛋白质的核酸也可用于预防HIV-1感染的建立或抑制HIV- 1复制。 本发明提供了与这些发现相关的用途，方法和组合。
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