-
公开(公告)号:US20110218182A1
公开(公告)日:2011-09-08
申请号:US13000138
申请日:2009-07-02
申请人: Leslie Dakin , James Edward Dowling , Michelle Lamb , Jon Read , Qibin Su , Xiaolan Zheng
发明人: Leslie Dakin , James Edward Dowling , Michelle Lamb , Jon Read , Qibin Su , Xiaolan Zheng
IPC分类号: A61K31/427 , C07D417/10 , A61K31/454 , C12N9/99 , A61P35/00 , A61K31/551 , A61K31/496 , C07D417/14 , A61K31/5377 , A61K31/541
CPC分类号: C07D417/10 , A61K31/426 , A61K31/427 , C07D277/34 , C07D417/06 , C07D417/12 , C07D417/14
摘要: The invention relates to chemical compounds of formula (I), and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of PIM-1 and/or PIM-2, and/or PIM-3 protein kinase activity or enzyme function. In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein, and their use in the prevention and treatment of PIM kinase related conditions and diseases, preferably cancer.
摘要翻译: 本发明涉及式(I)化合物及其盐。 在一些实施方案中,本发明涉及PIM-1和/或PIM-2和/或PIM-3蛋白激酶活性或酶功能的抑制剂或调节剂。 在另外的实施方案中,本发明涉及包含本文公开的化合物的药物组合物及其在预防和治疗PIM激酶相关病症和疾病,优选癌症中的用途。
-
公开(公告)号:US08901307B2
公开(公告)日:2014-12-02
申请号:US13000138
申请日:2009-07-02
申请人: Leslie Dakin , James Edward Dowling , Michelle Lamb , Jon Read , Xiaolan Zheng
发明人: Leslie Dakin , James Edward Dowling , Michelle Lamb , Jon Read , Xiaolan Zheng
IPC分类号: C07D417/10 , A61K31/454 , C07D417/14 , A61K31/427 , C07D277/34 , C07D417/06 , A61K31/426
CPC分类号: C07D417/10 , A61K31/426 , A61K31/427 , C07D277/34 , C07D417/06 , C07D417/12 , C07D417/14
摘要: The invention relates to chemical compounds of formula (I), and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of PIM-1 and/or PIM-2, and/or PIM-3 protein kinase activity or enzyme function. In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein, and their use in the prevention and treatment of PIM kinase related conditions and diseases, preferably cancer.
摘要翻译: 本发明涉及式(I)化合物及其盐。 在一些实施方案中,本发明涉及PIM-1和/或PIM-2和/或PIM-3蛋白激酶活性或酶功能的抑制剂或调节剂。 在另外的实施方案中,本发明涉及包含本文公开的化合物的药物组合物及其在预防和治疗PIM激酶相关病症和疾病,优选癌症中的用途。
-