公开(公告)号：US20080139625A1

公开(公告)日：2008-06-12

申请号：US11632675

申请日：2005-04-29

申请人： Libuse Jaroskova ,  Joannes Theodorus Maria Linders ,  Christophe Francis Robert Nestor Buyck ,  Louis Jozef Elizabeth Van Der Veken ,  Vladimir Dimichev Dimitrov ,  Theo Teofanov Nikiforov

发明人： Libuse Jaroskova ,  Joannes Theodorus Maria Linders ,  Christophe Francis Robert Nestor Buyck ,  Louis Jozef Elizabeth Van Der Veken ,  Vladimir Dimichev Dimitrov ,  Theo Teofanov Nikiforov

IPC分类号： A61K31/4015 ,  C07D207/12 ,  C07D405/10 ,  A61P3/00 ,  A61K31/4412 ,  C07D211/40

CPC分类号： C07D211/76 ,  C07D207/26 ,  C07D207/267 ,  C07D405/06

摘要： Formula (I), the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein n is 1 or 2; L represents a C1-3alkyl linker optionally substituted with one or two substituents selected from C1-4alkyl, C1-3alkyloxy-C1-4alkyl-, hydroxy-C1-4alkyl, hydroxy, C1-3alkyloxy- or phenyl-C1-4alkyl; M represents a direct bond or a C1-3alkyl linker optionally substituted with one or two substituents selected from hydroxy, C1-4alkyl or C1-4alkyloxy; R1 and R2 each independently represent hydrogen, halo, cyano, hydroxy, C1-4alkyl optionally substituted with halo, C1-4alkyloxy- optionally substituted with one or where possible two or three substituents selected from hydroxy, Ar1 and halo; or R1 and R2 taken together with the phenyl ring to which they are attached form naphtyl or 1,3-benzodioxolyl, wherein said naphtyl or 1,3-benzodioxolyl are optionally substituted with halo; R3 represents hydrogen, halo, C1-4alkyl, C1-4alkyloxy-, cyano or hydroxy; R4 represents hydrogen, halo, C1-4alkyl, C1-4alkyloxy-, cyano or hydroxy; R5 represents hydrogen, C1-4alkyl or Ar2-C1-4alky-; R6 represents hydrogen, halo, C1-4alkyl Or C1-4alkyoxy-; Ar1 and Ar2 each independently represent phenyl or naphtyl wherein said phenyl and naphtyl are optionally substituted with C1-4alkyl, C1-4alkyloxy-, or phenyl-C1-4alkyl; for use as a medicine.