公开(公告)号：US20220380310A1

公开(公告)日：2022-12-01

申请号：US17624348

申请日：2020-06-29

申请人： Ligang QIAN ,  Chunbo ZHANG

发明人： Ligang QIAN ,  Chunbo ZHANG

IPC分类号： C07D211/96 ,  C07D401/12 ,  C07D413/12 ,  C07D405/12 ,  C07D211/56 ,  C07D241/06

摘要： A compound has Formula I: R1 is hydrogen, hydroxy, halogen, nitro, amino, alkyl, alkoxy, alkylamino, cycloalkyl, cycloalkyamino, heterocyclyl, aryl, heteroaryl, —NR7R8, —CO—R10, or —NH—CO—R10; L is a bond, a heterocyclic bivalent group, a heteroaromatic bivalent group, or an aromatic bivalent group; M is a bond, alkyl, aryl, heterocyclic bivalent group, heteroaromatic bivalent group, or aromatic bivalent group; X is a bond, —O—, —S—, —SO2—, —CO—, —NR9—, —(CH2)m—, or heterocyclic bivalent group, m is 1, 2, 3, 4, 5, or 6; Y is a bond, —NH—, heterocyclic bivalent group, heteroaromatic bivalent group, bivalent benzyl group, or aromatic bivalent group; and Z is hydrogen, halogen, alkyl, aryl, heterocyclyl, heteroaryl, —NR7R8, —CO—R10, or —NH—CO—R10; R7, R8, and R9 are independently hydrogen, hydroxy, halogen, nitro, amino, alkyl, alkoxy, alkylamino, cycloalkyl, cycloalkyamino, heterocyclyl, or heteroaryl; and R10 is —O-tert-butyl, —CH2CH2-phenyl, hydrogen, hydroxy, halogen, nitro, amino, alkyl, alkoxy, alkylamino, cycloalkyl, cycloalkyamino, heterocyclyl, or heteroaryl.