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公开(公告)号：US20070287859A1
公开(公告)日：2007-12-13
申请号：US11893235
申请日：2007-08-14
申请人： Lilach Hedvati , Dee-Noor Ziv , Claude Singer , Gideon Pilarski
发明人： Lilach Hedvati , Dee-Noor Ziv , Claude Singer , Gideon Pilarski
IPC分类号： C07B57/00
CPC分类号： C07C215/30 , C07C227/16 , C07C229/08 , C07C231/20 , C07C233/05
摘要： The invention relates to pure (R)-CMH and to the optical resolution of CMH-racemate, a key intermediate in the synthesis of (S)-Pregabalin. The invention also relates to the process for optically purifying (R)-CMH and to the process for isolating (S)-CMH from the mother liquor.
摘要翻译： 本发明涉及纯（R）-CMH和涉及（S）-Pregabalin合成中关键中间体的CMH-外消旋体的光学拆分。 本发明还涉及用于光学纯化（R）-CMH的方法和从母液中分离（S）-CMH的方法。
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公开(公告)号：US20070073085A1
公开(公告)日：2007-03-29
申请号：US11432721
申请日：2006-05-10
申请人： Lilach Hedvati , Ziv Dee Noor , Claude Singer , Gideon Pilarski
发明人： Lilach Hedvati , Ziv Dee Noor , Claude Singer , Gideon Pilarski
IPC分类号： C07C229/02
CPC分类号： C07C227/16 , C07C227/20 , C07C227/32 , C07C229/08
摘要： Processes for preparing and purifying Pregabalin and salts thereof are provided.
摘要翻译： 提供了制备和纯化普瑞巴林及其盐的方法。
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公开(公告)号：US07678938B2
公开(公告)日：2010-03-16
申请号：US11893235
申请日：2007-08-14
申请人： Lilach Hedvati , Ziv Dee-Noor , Claude Singer , Gideon Pilarski
发明人： Lilach Hedvati , Ziv Dee-Noor , Claude Singer , Gideon Pilarski
IPC分类号： C07B57/00 , C07C227/30
CPC分类号： C07C215/30 , C07C227/16 , C07C229/08 , C07C231/20 , C07C233/05
摘要： The invention relates to pure (R)-CMH and to the optical resolution of CMH-racemate, a key intermediate in the synthesis of (S)-Pregabalin. The invention also relates to the process for optically purifying (R)-CMH and to the process for isolating (S)-CMH from the mother liquor.
摘要翻译： 本发明涉及纯（R）-CMH和涉及（S）-Pregabalin合成中关键中间体的CMH-外消旋体的光学拆分。 本发明还涉及用于光学纯化（R）-CMH的方法和从母液中分离（S）-CMH的方法。
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公开(公告)号：US07488846B2
公开(公告)日：2009-02-10
申请号：US11402415
申请日：2006-04-11
申请人： Lilach Hedvati , Gideon Pilarski , Yuriy Raizi , Sharon Tomer , Ziv Dee-Noor , Claude Singer
发明人： Lilach Hedvati , Gideon Pilarski , Yuriy Raizi , Sharon Tomer , Ziv Dee-Noor , Claude Singer
IPC分类号： C07C227/00
CPC分类号： C07C229/08
摘要： The present invention encompasses Pregabalin substantially free of Lactam and a process for obtaining Pregabalin substantially free of Lactam comprising extracting an acidic mixture containing a complex of Pregabalin with a strong mineral acid, with C3-8 alcohol; and combining the organic phase with an organic base.
摘要翻译： 本发明包括基本上不含内酰胺的普瑞巴林和用于获得基本上不含内酰胺的普瑞巴林的方法，其包括用C3-8醇提取含有普瑞巴林与强无机酸的复合物的酸性混合物; 并将有机相与有机碱结合。
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5.发明授权公开(公告)号：US07462737B2
公开(公告)日：2008-12-09
申请号：US11432090
申请日：2006-05-10
申请人： Lilach Hedvati , Ziv Dee-Noor , Claude Singer , Gideon Pilarski , Yuriy Raizi , Sharon Tomer
发明人： Lilach Hedvati , Ziv Dee-Noor , Claude Singer , Gideon Pilarski , Yuriy Raizi , Sharon Tomer
IPC分类号： C07C205/00
CPC分类号： C07C227/40 , C07C227/42 , C07C229/08
摘要： A Pregabalin having a low level of 3-isobutylglutaric acid is provided.
摘要翻译： 提供了具有低水平的3-异丁基戊二酸的普瑞巴林。
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公开(公告)号：US07619112B2
公开(公告)日：2009-11-17
申请号：US11893216
申请日：2007-08-14
申请人： Lilach Hedvati , Ziv Dee-Noor , Claude Singer , Gideon Pilarski
发明人： Lilach Hedvati , Ziv Dee-Noor , Claude Singer , Gideon Pilarski
IPC分类号： C07C55/00
CPC分类号： C07C215/30 , C07C227/16 , C07C229/08 , C07C231/20 , C07C233/05
摘要： The invention relates to pure (R)—CMH and to the optical resolution of CMH-racemate, a key intermediate in the synthesis of (S)-Pregabalin. The invention also relates to the process for optically purifying (R)—CMH and to the process for isolating (S)—CMH from the mother liquor.
摘要翻译： 本发明涉及纯（R）-CMH和涉及（S）-Pregabalin合成中关键中间体的CMH-外消旋体的光学拆分。 本发明还涉及用于光学纯化（R）-CMH的方法和从母液中分离（S）-CMH的方法。
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公开(公告)号：US20070287860A1
公开(公告)日：2007-12-13
申请号：US11893300
申请日：2007-08-14
申请人： Lilach Hedvati , Ziv Dee-Noor , Claude Singer , Gideon Pilarski
发明人： Lilach Hedvati , Ziv Dee-Noor , Claude Singer , Gideon Pilarski
IPC分类号： C07B57/00
CPC分类号： C07C215/30 , C07C227/16 , C07C229/08 , C07C231/20 , C07C233/05
摘要： The invention relates to pure (R)—CMH and to the optical resolution of CMH-racemate, a key intermediate in the synthesis of (S)-Pregabalin. The invention also relates to the process for optically purifying (R)—CMH and to the process for isolating (S)—CMH from the mother liquor.
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公开(公告)号：US20070287748A1
公开(公告)日：2007-12-13
申请号：US11893216
申请日：2007-08-14
申请人： Lilach Hedvati , Ziv Dee-Noor , Claude Singer , Gideon Pilarski
发明人： Lilach Hedvati , Ziv Dee-Noor , Claude Singer , Gideon Pilarski
IPC分类号： A61K31/195 , C07C229/08
CPC分类号： C07C215/30 , C07C227/16 , C07C229/08 , C07C231/20 , C07C233/05
摘要： The invention relates to pure (R)—CMH and to the optical resolution of CMH-racemate, a key intermediate in the synthesis of (S)-Pregabalin. The invention also relates to the process for optically purifying (R)—CMH and to the process for isolating (S)—CMH from the mother liquor.
摘要翻译： 本发明涉及纯（R）-CMH和涉及（S）-Pregabalin合成中关键中间体的CMH-外消旋体的光学拆分。 本发明还涉及用于光学纯化（R）-CMH的方法和从母液中分离（S）-CMH的方法。
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公开(公告)号：US20070043241A1
公开(公告)日：2007-02-22
申请号：US11432010
申请日：2006-05-10
申请人： Lilach Hedvati , Ziv Dee-Noor , Claude Singer , Gideon Pilarski
发明人： Lilach Hedvati , Ziv Dee-Noor , Claude Singer , Gideon Pilarski
IPC分类号： C07C237/02
CPC分类号： C07C215/30 , C07C227/16 , C07C229/08 , C07C231/20 , C07C233/05
摘要： The invention relates to pure (R)—CMH and to the optical resolution of CMH-racemate, a key intermediate in the synthesis of (S)-Pregabalin. The invention also relates to the process for optically purifying (R)—CMH and to the process for isolating (S)—CMH from the mother liquor.
摘要翻译： 本发明涉及纯（R）-CMH和涉及（S）-Pregabalin合成中关键中间体的CMH-外消旋体的光学拆分。 本发明还涉及用于光学纯化（R）-CMH的方法和从母液中分离（S）-CMH的方法。
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公开(公告)号：US20060281816A1
公开(公告)日：2006-12-14
申请号：US11402415
申请日：2006-04-11
申请人： Lilach Hedvati , Gideon Pilarski , Yuriy Raizi , Sharon Tomer , Ziv Dee-Noor , Claude Singer
发明人： Lilach Hedvati , Gideon Pilarski , Yuriy Raizi , Sharon Tomer , Ziv Dee-Noor , Claude Singer
IPC分类号： A61K31/195 , C07C229/28
CPC分类号： C07C229/08
摘要： The present invention encompasses Pregabalin substantially free of Lactam and a process for obtaining Pregabalin substantially free of Lactam comprising extracting an acidic mixture containing a complex of Pregabalin with a strong mineral acid, with a C3-8 alcohol; and combining the organic phase with an organic base.
摘要翻译： 本发明包括基本上不含内酰胺的普瑞巴林，以及获得基本上不含内酰胺的普瑞巴林的方法，其包括用C 3〜3-8醇提取含有普瑞巴林与强无机酸的复合物的酸性混合物; 并将有机相与有机碱结合。
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