公开(公告)号：US20080063639A1

公开(公告)日：2008-03-13

申请号：US11783666

申请日：2007-04-11

申请人： Liliane Goetsch ,  Nathalie Corvaia ,  Olivier Leger ,  Alain Duflos ,  Jean-Francois Haeuw ,  Alain Beck ,  Yann Duflos

发明人： Liliane Goetsch ,  Nathalie Corvaia ,  Olivier Leger ,  Alain Duflos ,  Jean-Francois Haeuw ,  Alain Beck ,  Yann Duflos

IPC分类号： A61K39/395 ,  A61P17/06

CPC分类号： A61K47/6805 ,  C07K2317/732

摘要： The present invention relates to a method for the prevention or for the treatment of psoriasis comprising administering to a patient in need thereof an effective amount of an isolated antibody, or one of its functional fragments, capable of binding to the human insulin-like growth factor I receptor IGF-IR. The present invention is also directed to said method wherein a second compound selected from the compounds capable of specifically inhibiting the attachment of the EGF to the human epidermal growth factor receptor EGFR, such as an isolated anti-EGFR antibody, or a functional fragment thereof, is administered to the patient in addition to the anti-IGR-IR antibody.

摘要翻译： 本发明涉及一种预防或治疗牛皮癣的方法，包括向有需要的患者施用有效量的能够结合人类胰岛素样生长因子的分离抗体或其功能片段之一 I受体IGF-1R。 本发明还涉及所述方法，其中选自能够特异性抑制EGF与人表皮生长因子受体EGFR（例如分离的抗EGFR抗体或其功能片段）附着的化合物的第二化合物， 除了抗IGR-IR抗体外还施用于患者。