公开(公告)号：US09050353B2

公开(公告)日：2015-06-09

申请号：US13703168

申请日：2011-06-07

申请人： Lin Li ,  Linlin Yin ,  Lili Lin ,  Lan Zhang ,  Wen Wang ,  Ruyi Zhang

发明人： Lin Li ,  Linlin Yin ,  Lili Lin ,  Lan Zhang ,  Wen Wang ,  Ruyi Zhang

IPC分类号： A61K31/7048 ,  A61K36/296

CPC分类号： A61K31/7048 ,  A61K36/296

摘要： New use of icariin and Epimedium flavaoids containing icariin is provided by the present invention. Specifically, uses of compounds of Formula I or Epimedium containing compounds of formula I, Epimedium flavanoids, or extracts of Epimedium in manufacturing medicaments for treating, preventing, reducing and/or relieving diseases and/or conditoins related to neural myelin sheath impairments, or use of above materials in manufacturing medicaments for relieving demyelination and/or promoting repair of myelin sheath are provided by the present application, wherein, R1 is selected from H, halogen, —C1-6 alkyl, and —C(O)—C1-4 alkyl

摘要翻译： 本发明提供了新的使用含淫羊藿苷和淫羊藿苷的淫羊藿苷。 具体地，在制备用于治疗，预防，减少和/或减轻与神经髓鞘损伤相关的疾病和/或状况的药物中使用式I化合物或含淫羊藿的式I化合物，淫羊藿苷或淫羊藿提取物的用途或用途 在本申请中提供了用于缓解脱髓鞘和/或促进髓鞘的修复的药物的上述材料，其中R 1选自H，卤素，-C 1-6烷基和-C（O）-C1-4 烷基

公开(公告)号：US20130157966A1

公开(公告)日：2013-06-20

申请号：US13703168

申请日：2011-06-07

申请人： Lin Li ,  Linlin Yin ,  Lili Lin ,  Lan Zhang ,  Wen Wang ,  Ruyi Zhang

发明人： Lin Li ,  Linlin Yin ,  Lili Lin ,  Lan Zhang ,  Wen Wang ,  Ruyi Zhang

IPC分类号： A61K31/7048

CPC分类号： A61K31/7048 ,  A61K36/296

摘要： New use of icariin and Epimedium flavaoids containing icariin is provided by the present invention. Specifically, uses of compounds of Formula I or Epimedium containing compounds of formula I, Epimedium flavanoids, or extracts of Epimedium in manufacturing medicaments for treating, preventing, reducing and/or relieving diseases and/or conditoins related to neural myelin sheath impairments, or use of above materials in manufacturing medicaments for relieving demyelination and/or promoting repair of myelin sheath are provided by the present application, wherein, R1 is selected from H, halogen, —C1-6 alkyl, and —C(O)—C1-4 alkyl

摘要翻译： 本发明提供了新的使用含淫羊藿苷和淫羊藿苷的淫羊藿苷。 具体地，在制备用于治疗，预防，减少和/或减轻与神经髓鞘损伤相关的疾病和/或状况的药物中使用式I化合物或含淫羊藿的式I化合物，淫羊藿苷或淫羊藿提取物的用途或用途 在本申请中提供了用于缓解脱髓鞘和/或促进髓鞘的修复的药物的上述材料，其中R 1选自H，卤素，-C 1-6烷基和-C（O）-C1-4 烷基

公开(公告)号：US09233116B2

公开(公告)日：2016-01-12

申请号：US13703170

申请日：2010-12-15

申请人： Lin Li ,  Linlin Yin ,  Lan Zhang ,  Wen Wang ,  Ruyi Zhang

发明人： Lin Li ,  Linlin Yin ,  Lan Zhang ,  Wen Wang ,  Ruyi Zhang

IPC分类号： A01N43/04 ,  A61K31/70 ,  C07H15/24 ,  A61K31/7048 ,  A61K36/40

CPC分类号： A61K31/7048 ,  A61K36/40

摘要： Composition containing iridoids such as morroniside and loganin, the use thereof in preparing medicaments for preventing and treating neurologic demyelinating diseases, and the method thereof in treating diseases related to neurologic demyelinating lesions are disclosed by the present application.

摘要翻译： 本发明公开了含有环烯醚萜如莫洛膦酸和洛迦宁的组合物及其在制备用于预防和治疗神经性脱髓鞘疾病的药物中的用途及其在治疗与神经性脱髓鞘病变有关的疾病中的应用。

公开(公告)号：US20130116205A1

公开(公告)日：2013-05-09

申请号：US13703170

申请日：2010-12-15

申请人： Lin Li ,  Linlin Yin ,  Lan Zhang ,  Wen Wang ,  Ruyi Zhang

发明人： Lin Li ,  Linlin Yin ,  Lan Zhang ,  Wen Wang ,  Ruyi Zhang

IPC分类号： A61K31/7048

CPC分类号： A61K31/7048 ,  A61K36/40

摘要： Composition containing iridoids such as morroniside and loganin, the use thereof in preparing medicaments for preventing and treating neurologic demyelinating diseases, and the method thereof in treating diseases related to neurologic demyelinating lesions are disclosed by the present application.

摘要翻译： 本发明公开了含有环烯醚萜如莫洛膦酸和洛豫素的组合物，其在制备用于预防和治疗神经性脱髓鞘疾病的药物中的用途及其治疗与神经性脱髓鞘病变有关的疾病的方法。