公开(公告)号：US20120039881A1

公开(公告)日：2012-02-16

申请号：US13278417

申请日：2011-10-21

申请人： Lin Mei ,  Wen-Cheng Xiong ,  Ran-Sook Woo ,  Xiaoming Li

发明人： Lin Mei ,  Wen-Cheng Xiong ,  Ran-Sook Woo ,  Xiaoming Li

IPC分类号： A61K39/395 ,  A61K38/18 ,  A61K39/00 ,  A61P25/22 ,  A61P25/18 ,  A61P25/08 ,  A61P25/24 ,  A61K38/45 ,  A61P25/00

CPC分类号： A61K39/3955 ,  A61K38/177 ,  A61K38/1883 ,  A61K38/45

摘要： Methods and compositions for modulating GABA release in a subject are provided. A preferred embodiment provides a composition containing an effective amount of an ErbB4 ligand to enhance or promote GABA release, i.e., GABAergic transmission. The ErbB4 ligand can be an agonist ligand or an antagonist ligand depending on the disorder to be treated. Methods for treating neurological disorders are also provided. Representative disorders that can be treated include, but are not limited to schizophrenia, epilepsy, depression and anxiety, insomnia, stroke, pain, bipolar, autism, or a combination thereof. By increasing GABA release a sedative effective can be induced in the subject. Methods for inducing a stimulatory effect in a subject are also provided. In these methods, an effective amount of an ErbB4 antagonist ligand is administered to the subject to reduce or inhibit GABA release in the subject.

摘要翻译： 提供了用于调节受试者中GABA释放的方法和组合物。 优选的实施方案提供含有有效量的ErbB4配体的组合物以增强或促进GABA释放，即GABA能传递。 根据待治疗的病症，ErbB4配体可以是激动剂配体或拮抗剂配体。 还提供了治疗神经障碍的方法。 可以治疗的代表性疾病包括但不限于精神分裂症，癫痫，抑郁和焦虑，失眠，中风，疼痛，双相，孤独症或其组合。 通过增加GABA释放可以在受试者中诱导镇静作用。 还提供了在受试者中诱导刺激作用的方法。 在这些方法中，向受试者施用有效量的ErbB4拮抗剂配体以减少或抑制受试者中的GABA释放。