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![CRYSTALLINE FORM OF A 4-[2-(2-FLUOROPHENOXYMETHYL)PHENYL]PIPERIDINE COMPOUND](/abs-image/US/2010/05/20/US20100125093A1/abs.jpg.150x150.jpg)
1.发明申请CRYSTALLINE FORM OF A 4-[2-(2-FLUOROPHENOXYMETHYL)PHENYL]PIPERIDINE COMPOUND 有权4- [2-（2-氟甲氧基甲基）苯基]哌啶化合物的晶体形式公开(公告)号：US20100125093A1
公开(公告)日：2010-05-20
申请号：US12617838
申请日：2009-11-13
IPC分类号： A61K31/4465 , C07D211/22
CPC分类号： A61K31/4465 , C07D211/22 , C07D211/32
摘要： The invention provides a crystalline hydrochloride salt of 4-[2-(2,4,6-trifluorophenoxymethyl)phenyl]piperidine. This invention also provides pharmaceutical compositions comprising the crystalline salt, processes and intermediates for preparing the crystalline salt, and methods of using the crystalline salt to treat diseases.
摘要翻译： 本发明提供4- [2-（2,4,6-三氟苯氧基甲基）苯基]哌啶的结晶盐酸盐。 本发明还提供了包含结晶盐，用于制备结晶盐的方法和中间体以及使用结晶盐治疗疾病的方法的药物组合物。
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![CRYSTALLINE FORM OF A 4-[2-(2-FLUOROPHENOXYMETHYL)PHENYL]PIPERIDINE COMPOUND](/abs-image/US/2013/01/31/US20130030185A1/abs.jpg.150x150.jpg)
2.发明申请CRYSTALLINE FORM OF A 4-[2-(2-FLUOROPHENOXYMETHYL)PHENYL]PIPERIDINE COMPOUND 有权4- [2-（2-氟甲氧基甲基）苯基]哌啶化合物的晶体形式公开(公告)号：US20130030185A1
公开(公告)日：2013-01-31
申请号：US13632588
申请日：2012-10-01
IPC分类号： C07D211/22
CPC分类号： A61K31/4465 , C07D211/22 , C07D211/32
摘要： The invention provides a crystalline hydrochloride salt of 4-[2-(2,4,6-trifluorophenoxymethyl)phenyl]piperidine. This invention also provides pharmaceutical compositions comprising the crystalline salt, processes and intermediates for preparing the crystalline salt, and methods of using the crystalline salt to treat diseases.
摘要翻译： 本发明提供4- [2-（2,4,6-三氟苯氧基甲基）苯基]哌啶的结晶盐酸盐。 本发明还提供了包含结晶盐，用于制备结晶盐的方法和中间体以及使用结晶盐治疗疾病的方法的药物组合物。
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![CRYSTALLINE FORM OF A 4-[2-(2-FLUOROPHENOXYMETHYL)PHENYL]PIPERIDINE COMPOUND](/abs-image/US/2016/01/28/US20160022660A1/abs.jpg.150x150.jpg)
公开(公告)号：US20160022660A1
公开(公告)日：2016-01-28
申请号：US14728079
申请日：2015-06-02
IPC分类号： A61K31/4465
CPC分类号： A61K31/4465 , C07D211/22 , C07D211/32
摘要： The invention provides a crystalline hydrochloride salt of 4-[2-(2,4,6-trifluorophenoxymethyl)phenyl]piperidine. This invention also provides pharmaceutical compositions comprising the crystalline salt, processes and intermediates for preparing the crystalline salt, and methods of using the crystalline salt to treat diseases.
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![Crystalline form of a 4-[2-(2-fluorophenoxymethyl) phenyl]piperidine compound](/abs-image/US/2015/07/07/US09073859B2/abs.jpg.150x150.jpg)
4.发明授权Crystalline form of a 4-[2-(2-fluorophenoxymethyl) phenyl]piperidine compound 有权4- [2-（2-氟苯氧基甲基）苯基]哌啶化合物的结晶形式公开(公告)号：US09073859B2
公开(公告)日：2015-07-07
申请号：US14060846
申请日：2013-10-23
IPC分类号： A61K31/4409 , C07D211/22 , C07D211/32
CPC分类号： A61K31/4465 , C07D211/22 , C07D211/32
摘要： The invention provides a crystalline hydrochloride salt of 4-[2-(2,4,6-trifluorophenoxymethyl)phenyl]piperidine. This invention also provides pharmaceutical compositions comprising the crystalline salt, processes and intermediates for preparing the crystalline salt, and methods of using the crystalline salt to treat diseases.
摘要翻译： 本发明提供4- [2-（2,4,6-三氟苯氧基甲基）苯基]哌啶的结晶盐酸盐。 本发明还提供了包含结晶盐，用于制备结晶盐的方法和中间体以及使用结晶盐治疗疾病的方法的药物组合物。
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![Crystalline form of a 4-[2-(2-fluorophenoxymethyl)phenyl]piperidine compound](/abs-image/US/2012/11/06/US08304433B2/abs.jpg.150x150.jpg)
5.发明授权Crystalline form of a 4-[2-(2-fluorophenoxymethyl)phenyl]piperidine compound 有权4- [2-（2-氟苯氧基甲基）苯基]哌啶化合物的结晶形式公开(公告)号：US08304433B2
公开(公告)日：2012-11-06
申请号：US12617838
申请日：2009-11-13
IPC分类号： A61K31/4409 , C07D211/22
CPC分类号： A61K31/4465 , C07D211/22 , C07D211/32
摘要： The invention provides a crystalline hydrochloride salt of 4-[2-(2,4,6-trifluorophenoxymethyl)phenyl]piperidine. This invention also provides pharmaceutical compositions comprising the crystalline salt, processes and intermediates for preparing the crystalline salt, and methods of using the crystalline salt to treat diseases.
摘要翻译： 本发明提供4- [2-（2,4,6-三氟苯氧基甲基）苯基]哌啶的结晶盐酸盐。 本发明还提供了包含结晶盐，用于制备结晶盐的方法和中间体以及使用结晶盐治疗疾病的方法的药物组合物。
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![CRYSTALLINE FORM OF A 4-[2-(2-FLUOROPHENOXYMETHYL) PHENYL]PIPERIDINE COMPOUND](/abs-image/US/2014/02/13/US20140045892A1/abs.jpg.150x150.jpg)
6.发明申请CRYSTALLINE FORM OF A 4-[2-(2-FLUOROPHENOXYMETHYL) PHENYL]PIPERIDINE COMPOUND 有权4- [2-（2-氟甲氧基甲基）苯基]哌啶化合物的晶体形式公开(公告)号：US20140045892A1
公开(公告)日：2014-02-13
申请号：US14060846
申请日：2013-10-23
IPC分类号： C07D211/22
CPC分类号： A61K31/4465 , C07D211/22 , C07D211/32
摘要： The invention provides a crystalline hydrochloride salt of 4-[2-(2,4,6-trifluorophenoxymethyl)phenyl]piperidine. This invention also provides pharmaceutical compositions comprising the crystalline salt, processes and intermediates for preparing the crystalline salt, and methods of using the crystalline salt to treat diseases.
摘要翻译： 本发明提供4- [2-（2,4,6-三氟苯氧基甲基）苯基]哌啶的结晶盐酸盐。 本发明还提供了包含结晶盐，用于制备结晶盐的方法和中间体以及使用结晶盐治疗疾病的方法的药物组合物。
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公开(公告)号：US08476299B2
公开(公告)日：2013-07-02
申请号：US13328386
申请日：2011-12-16
IPC分类号： A61K31/04
CPC分类号： C07D401/12
摘要： The invention provides a crystalline 1,2-ethanedisulfonic acid salt of biphenyl-2-ylcarbamic acid 1-[2-(2-chloro-4-{[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]methyl}-5-methoxyphenylcarbamoyl)ethyl]piperidin-4-yl ester or a solvate thereof. This invention also provides pharmaceutical compositions comprising such a salt or prepared using such a salt; processes and intermediates for preparing such a salt; and methods of using such a salt to treat a pulmonary disorder.
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公开(公告)号：US08101766B2
公开(公告)日：2012-01-24
申请号：US12369605
申请日：2009-02-11
IPC分类号： C07D215/38
CPC分类号： C07D401/12
摘要： The invention provides a crystalline 1,2-ethanedisulfonic acid salt of biphenyl-2-ylcarbamic acid 1-[2-(2-chloro-4-{[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]methyl}-5-methoxyphenylcarbamoyl)ethyl]piperidin-4-yl ester or a solvate thereof. This invention also provides pharmaceutical compositions comprising such a salt or prepared using such a salt; processes and intermediates for preparing such a salt; and methods of using such a salt to treat a pulmonary disorder.
摘要翻译： 本发明提供联苯-2-基氨基甲酸1- [2-（2-氯-4 - {[（R）-2-羟基-2-（8-羟基-2- -2-氧代-1,2-二氢喹啉-5-基）乙基氨基]甲基} -5-甲氧基苯基氨基甲酰基）乙基]哌啶-4-基酯或其溶剂合物。 本发明还提供了包含这种盐或使用这种盐制备的药物组合物; 制备这种盐的方法和中间体; 以及使用这种盐治疗肺部疾病的方法。
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公开(公告)号：US20090221638A1
公开(公告)日：2009-09-03
申请号：US12369605
申请日：2009-02-11
IPC分类号： A61K31/4709 , A61P35/00
CPC分类号： C07D401/12
摘要： The invention provides a crystalline 1,2-ethanedisulfonic acid salt of biphenyl-2-ylcarbamic acid 1-[2-(2-chloro-4-{[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5 -yl)ethylamino]methyl}-5-methoxyphenylcarbamoyl)ethyl]piperidin-4-yl ester or a solvate thereof. This invention also provides pharmaceutical compositions comprising such a salt or prepared using such a salt; processes and intermediates for preparing such a salt; and methods of using such a salt to treat a pulmonary disorder.
摘要翻译： 本发明提供联苯-2-基氨基甲酸1- [2-（2-氯-4 - {[（R）-2-羟基-2-（8-羟基-2- -2-氧代-1,2-二氢喹啉-5-基）乙基氨基]甲基} -5-甲氧基苯基氨基甲酰基）乙基]哌啶-4-基酯或其溶剂合物。 本发明还提供了包含这种盐或使用这种盐制备的药物组合物; 制备这种盐的方法和中间体; 以及使用这种盐治疗肺部疾病的方法。
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公开(公告)号：US07521558B2
公开(公告)日：2009-04-21
申请号：US11204065
申请日：2005-08-15
IPC分类号： C07D453/04 , C07D211/56
CPC分类号： C07D401/12
摘要： The invention provides a crystalline 1,2-ethanedisulfonic acid salt of biphenyl-2-ylcarbamic acid 1-[2-(2-chloro-4-{[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]methyl}-5-methoxyphenylcarbamoyl)ethyl]piperidin-4-yl ester or a solvate thereof. This invention also provides pharmaceutical compositions comprising such a salt or prepared using such a salt; processes and intermediates for preparing such a salt; and methods of using such a salt to treat a pulmonary disorder.
摘要翻译： 本发明提供联苯-2-基氨基甲酸1- [2-（2-氯-4 - {[（R）-2-羟基-2-（8-羟基-2- -2-氧代-1,2-二氢喹啉-5-基）乙基氨基]甲基} -5-甲氧基苯基氨基甲酰基）乙基]哌啶-4-基酯或其溶剂合物。 本发明还提供了包含这种盐或使用这种盐制备的药物组合物; 制备这种盐的方法和中间体; 以及使用这种盐治疗肺部疾病的方法。
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