专利检索 ap:("Lorne M. Golub" OR "Nungavarum S. Ramamurthy" OR "Thomas F. McNamara" OR "Maria E. Ryan") AND inv:"Nungavarum S. Ramamurthy" 第 1 页

1.

发明授权
Tetracyclines including non-antimicrobial chemically-modified tetracyclines inhibit excessive glycosylation of different types of collagen and other proteins during diabetes 失效
标题翻译：四环素包括非抗微生物化学修饰的四环素抑制糖尿病期间不同类型胶原蛋白和其他蛋白质的过度糖基化

公开(公告)号：US5532227A

公开(公告)日：1996-07-02

申请号：US361116

申请日：1994-12-21

申请人： Lorne M. Golub , Nungavarum S. Ramamurthy , Thomas F. McNamara , Maria E. Ryan

发明人： Lorne M. Golub , Nungavarum S. Ramamurthy , Thomas F. McNamara , Maria E. Ryan

IPC分类号： A61K31/65 , A61P3/08 , A61P3/10 , A61P17/00 , A61P43/00 , C07C237/26

CPC分类号： A61K31/65 , Y10S514/866 , Y10S514/912

摘要： A method for treating mammals suffering from excessive extracellular protein glycosylation which is associated with diabetes, scleroderma and progeria by administering to the mammal a tetracycline which effectively inhibits excessive protein glycosylation.

摘要翻译： 通过向哺乳动物施用有效抑制过量蛋白质糖基化的四环素来治疗患有与糖尿病，硬皮病和原发性相关的过度细胞外蛋白质糖基化的哺乳动物的方法。