公开(公告)号：US5681584A

公开(公告)日：1997-10-28

申请号：US622238

申请日：1996-03-22

申请人： Louis Savastano ,  James Carr ,  Elizabeth Quadros ,  Shailesh Shah ,  Satish Chaudra Khanna

发明人： Louis Savastano ,  James Carr ,  Elizabeth Quadros ,  Shailesh Shah ,  Satish Chaudra Khanna

IPC分类号： A61K9/00 ,  A61K9/22 ,  A61K9/24 ,  A61K9/28 ,  A61K9/30 ,  A61K9/52

CPC分类号： A61K9/2886 ,  A61K9/0004 ,  A61K9/209

摘要： A drug delivery device for delivering a drug either intermittently or to a pre-selected region of the gastro-intestinal tract, particularly to the colon, consists of an a solid core comprising an active agent coated with a delay jacket, then coated with a semi-permeable membrane which is optionally drilled to provide a release orifice, and then optionally further coated with an enteric material. The device delivers substantially all of the active agent to the targeted site.

摘要翻译： 用于将药物间歇地递送到胃肠道，特别是结肠的预先选择的区域的药物递送装置由包含涂覆有延迟护套的活性剂的固体芯组成，然后涂覆有半 可渗透的膜，其可选地钻出以提供释放孔，然后任选地进一步用肠溶性材料涂覆。 该设备将基本上所有的活性剂递送到目标位点。