公开(公告)号：US20130209527A1

公开(公告)日：2013-08-15

申请号：US13845515

申请日：2013-03-18

申请人： Lucilla DEL GAUDIO ,  Thomas Paul Lockhart ,  Alessandra Belloni ,  Rossella Bortolo ,  Roberto Tassinari

发明人： Lucilla DEL GAUDIO ,  Thomas Paul Lockhart ,  Alessandra Belloni ,  Rossella Bortolo ,  Roberto Tassinari

IPC分类号： B01F3/08

CPC分类号： B01F3/0811 ,  A61K9/1075 ,  B01F17/0085 ,  B01F2003/0823 ,  B01F2003/083 ,  C09K8/524 ,  C09K8/528 ,  C09K8/54 ,  C10L1/328

摘要： Process for the preparation of a water-in-oil or oil-in-water nanoemulsion wherein the dispersed phase is distributed in the dispersing phase in the form of droplets having a diameter ranging from 1 to 500 nm, comprising: 1) the preparation of a homogeneous water/oil blend (I) characterized by an interface tension lower than 1 mN/m, comprising water in an amount of 30 to 70% by weight, at least two surface-active agents having a different HLB, selected from non-ionic, anionic, polymeric surface-active agents, said surface-active agents being present in such a quantity as to make the blend homogeneous; 2) the dilution of the blend (I) in a dispersing phase consisting of oil or water with the addition of a surface-active agent, selected from non-ionic, anionic, polymeric surface-active agents, the quantity of the dispersing phase and surface--active agent being such as to obtain a nanoemulsion having a HLB different from that of the blend (I).

摘要翻译： 油包水或水包油纳米乳液的制备方法，其中分散相以直径为1至500nm的液滴形式分散在分散相中，包括：1）制备 特征在于界面张力低于1mN / m的均匀的水/油共混物（I），其包含30至70重量％的水，至少两种具有不同HLB的表面活性剂， 离子型，阴离子型，聚合型表面活性剂，所述表面活性剂的存在量使混合物均匀; 2）混合物（I）在由油或水组成的分散相中的稀释，加入选自非离子，阴离子，聚合表面活性剂的表面活性剂，分散相的量和 表面活性剂等获得具有不同于共混物（I）的HLB的纳米乳液。