公开(公告)号：US07074424B2

公开(公告)日：2006-07-11

申请号：US09996184

申请日：2001-11-28

申请人： Luis Z. Avila ,  Peter K. Jarrett ,  Hildegard M. Kramer ,  C. Michael Philbrook

发明人： Luis Z. Avila ,  Peter K. Jarrett ,  Hildegard M. Kramer ,  C. Michael Philbrook

IPC分类号： A61F2/02 ,  A61K47/30

CPC分类号： A61L31/041 ,  A61L24/043 ,  A61L27/26 ,  A61L27/34 ,  C08L71/02 ,  C08L2666/04 ,  C08L2666/26

摘要： Hyaluronic acid and polyalkylene glycol (PAG) based materials have been found to exhibit a synergistic interaction, in which the viscosity of the mixture is more than twice as high as the viscosity expected from the viscosity of the individual components. The mixture otherwise has similar properties to those of its constituents, and in particular will crosslink to form covalently crosslinked gels if the PEG carries crosslinkable groups. The viscous formulation adheres well to tissue, and has applications as a tissue sealant and in tissue coating, prevention of adhesions, cell immobilization, regeneration of cartilage, bone and other tissue, as well as in controlled delivery of hyaluronic acid to sites in the body. Related materials exhibit similar effects.

公开(公告)号：US07008635B1

公开(公告)日：2006-03-07

申请号：US09658390

申请日：2000-09-08

申请人： Arthur J. Coury ,  Stephen D. Goodrich ,  Hildegard M. Kramer ,  Luis Z. Avila ,  John F. Traverse ,  Peter K. Jarrett

发明人： Arthur J. Coury ,  Stephen D. Goodrich ,  Hildegard M. Kramer ,  Luis Z. Avila ,  John F. Traverse ,  Peter K. Jarrett

IPC分类号： A61F2/00 ,  A61K9/00 ,  A61K9/14

CPC分类号： A61K9/06

摘要： Hydrogels intended for orthopedic applications, including repair and regeneration of cartilage, bone, joint surfaces and related tissues, must possess greater strength and toughness than hydrogels used in soft tissue repair. A hydrogel formulation is provided which has high strength, toughness, a suitable mechanical modulus and low equilibrium hydration. It may also have controlled porosity or degradation time. It can be made to polymerize in situ with high (“good” to “excellent”) adherence to target tissue or surfaces. A preferred formulation for forming such gels comprises 40 to 80% by weight of a low-molecular weight polar monomer and 30 to 10% of a hydrophilic macromeric crosslinker.

公开(公告)号：US4810810A

公开(公告)日：1989-03-07

申请号：US762085

申请日：1985-08-02

申请人： Hildegard M. Kramer ,  Lewis S. Meriwether

发明人： Hildegard M. Kramer ,  Lewis S. Meriwether

IPC分类号： C07C31/32 ,  C07F5/06

CPC分类号： A61Q15/00 ,  A61K8/26 ,  A61K8/58 ,  C07C31/32 ,  C07F5/069 ,  A61K2800/58

摘要： A method for producing heterocyclic aluminum compounds of the formula:[(C.sub.3 H.sub.8 O.sub.2).sub.x (Al).sub.y (Cl).sub.z ]nwhere X=1, Y=1, Z=1-2, and n=1-20, by reacting aluminum chloride with a short chain alkanol or polyol in the presence of an inert solvent, and the composition obtained in the reaction which is useful as an anti-perspirant compound.

摘要翻译： 一种制备下式的杂环铝化合物的方法：通过使[（C 3 H 8 O 2）x（Al）y（Cl）z] n其中X = 1，Y = 1，Z = 1-2和n = 氯化铝与短链烷醇或多元醇在惰性溶剂的存在下反应，得到的组合物可用作抗渗透剂。