公开(公告)号：US10239869B2

公开(公告)日：2019-03-26

申请号：US15757103

申请日：2016-09-03

申请人： LUPIN LIMITED

发明人： Vidya Ramdas ,  Rajeshkumar Maganlal Loriya ,  Moloy Banerjee ,  Pradeep Rangrao Patil ,  Advait Arun Joshi ,  Laxmikant Shamlal Datrange ,  Deepak Sahebrao Walke ,  Talha Hussain Khan ,  Amit Kumar Das ,  Ganesh Navinchandra Gote ,  Vaibhav Madhukar Kalhapure ,  Venkata P. Palle ,  Rajender Kumar Kamboj

IPC分类号： C07D405/12 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  A61P29/00

摘要： The present invention relates to sulfonamide compounds Formula (I) wherein the substituents are as described herein, and their use in a medicine for the treatment of diseases, disorders associated with the inhibition of Voltage-gated sodium channels (VGSC) particularly NaV1.7. It further relates to the compounds herein and their pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof useful in treating diseases, disorders, syndromes and/or conditions associated with the inhibition of Voltage-gated sodium channels (VGSC) particularly NaV1.7. The invention also relates to process for the preparation of the compounds of the invention.

公开(公告)号：US20150010504A1

公开(公告)日：2015-01-08

申请号：US14375530

申请日：2013-02-09

申请人： Lupin Limited

发明人： Vidya Ramdas ,  Advait Arun Joshi ,  Moloy Manoj Banerjee ,  Amit Kumar Das ,  Deepak Sahebrao Walke ,  Venkata P. Palle ,  Rajender Kumar Kamboj

IPC分类号： C07D495/04 ,  C07D409/14 ,  C07D417/14 ,  A61K31/428 ,  A61K31/4178 ,  A61K45/06

CPC分类号： C07D495/04 ,  A61K31/4178 ,  A61K31/428 ,  A61K45/06 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14 ,  Y02A50/463

摘要： Disclosed are compounds of formula (I) for use as antiviral agents, particularly as anti-hepatitis virus C agents, wherein A, B, U, R1-R7, m, n, and q are as described herein. Also disclosed are pharmaceutical compositions and methods of treating or preventing viral infection in a host by the use of these compounds, either alone or in combination with other pharmaceutically active agents. Further disclosed are methods of preparing such compounds.

摘要翻译： 公开了用作抗病毒剂的式（I）化合物，特别是作为抗肝炎病毒C试剂，其中A，B，U，R 1 -R 7，m，n和q如本文所述。 还公开了通过使用这些化合物单独或与其它药物活性剂组合来治疗或预防宿主中病毒感染的药物组合物和方法。 进一步公开的是制备这些化合物的方法。

公开(公告)号：US20150010505A1

公开(公告)日：2015-01-08

申请号：US14375534

申请日：2013-02-08

申请人： Lupin Limited

发明人： Vidya Ramdas ,  Advait Arun Joshi ,  Moloy Manoj Banerjee ,  Amit Kumar Das ,  Deepak Sahebrao Walke ,  Venkata P. Palle ,  Rajender Kumar Kamboj

IPC分类号： C07D405/14 ,  A61K45/06 ,  A61K31/4178

CPC分类号： C07D495/04 ,  A61K31/4178 ,  A61K31/428 ,  A61K45/06 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14 ,  Y02A50/463

摘要： Disclosed are compounds of formula (I) for use as antiviral agents, particularly as anti-hepatitis virus C agents, wherein R-R 6 and q are as described herein. Also disclosed are pharmaceutical compositions and methods of treating or preventing viral infection in a host by the use of these compounds, either alone or in combination with other pharmaceutically active agents. Further disclosed are methods of preparing such compounds. (I).

摘要翻译： 公开了用作抗病毒剂的式（I）化合物，特别是作为抗肝炎病毒C试剂，其中R-R 6和q如本文所述。 还公开了通过使用这些化合物单独或与其它药物活性剂组合来治疗或预防宿主中病毒感染的药物组合物和方法。 进一步公开的是制备这些化合物的方法。 （一世）。

公开(公告)号：US09073943B2

公开(公告)日：2015-07-07

申请号：US14375534

申请日：2013-02-08

申请人： Lupin Limited

发明人： Vidya Ramdas ,  Advait Arun Joshi ,  Moloy Manoj Banerjee ,  Amit Kumar Das ,  Deepak Sahebrao Walke ,  Venkata P. Palle ,  Rajender Kumar Kamboj

IPC分类号： C07D405/14 ,  A61K31/4178 ,  A61K45/06 ,  C07D495/04 ,  C07D409/14 ,  C07D417/14 ,  A61K31/428

CPC分类号： C07D495/04 ,  A61K31/4178 ,  A61K31/428 ,  A61K45/06 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14 ,  Y02A50/463

摘要： Disclosed are compounds of formula (I) for use as antiviral agents, particularly as anti-hepatitis virus C agents, wherein R-R 6 and q are as described herein. Also disclosed are pharmaceutical compositions and methods of treating or preventing viral infection in a host by the use of these compounds, either alone or in combination with other pharmaceutically active agents. Further disclosed are methods of preparing such compounds. (I).

摘要翻译： 公开了用作抗病毒剂的式（I）化合物，特别是作为抗肝炎病毒C试剂，其中R-R 6和q如本文所述。 还公开了通过使用这些化合物单独或与其它药物活性剂组合来治疗或预防宿主中病毒感染的药物组合物和方法。 进一步公开的是制备这些化合物的方法。 （一世）。

公开(公告)号：US09073942B2

公开(公告)日：2015-07-07

申请号：US14375530

申请日：2013-02-09

申请人： Lupin Limited

发明人： Vidya Ramdas ,  Advait Arun Joshi ,  Moloy Manoj Banerjee ,  Amit Kumar Das ,  Deepak Sahebrao Walke ,  Venkata P. Palle ,  Rajender Kumar Kamboj

IPC分类号： C07D495/04 ,  C07D409/14 ,  C07D417/14 ,  A61K31/428 ,  A61K31/4178 ,  A61K45/06 ,  C07D405/14

CPC分类号： C07D495/04 ,  A61K31/4178 ,  A61K31/428 ,  A61K45/06 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14 ,  Y02A50/463

摘要： Disclosed are compounds of formula (I) for use as antiviral agents, particularly as anti-hepatitis virus C agents, wherein A, B, U, R1-R7, m, n, and q are as described herein. Also disclosed are pharmaceutical compositions and methods of treating or preventing viral infection in a host by the use of these compounds, either alone or in combination with other pharmaceutically active agents. Further disclosed are methods of preparing such compounds.

摘要翻译： 公开了用作抗病毒剂的式（I）化合物，特别是作为抗肝炎病毒C试剂，其中A，B，U，R 1 -R 7，m，n和q如本文所述。 还公开了通过使用这些化合物单独或与其它药物活性剂组合来治疗或预防宿主中病毒感染的药物组合物和方法。 进一步公开的是制备这些化合物的方法。