公开(公告)号：US20090275079A1

公开(公告)日：2009-11-05

申请号：US11976575

申请日：2007-10-25

申请人： Luppo Edens ,  Alard Van Albertus Dijk ,  Phillip Krubasik ,  Kaj Albermann ,  Alexander Stock ,  Erik Kimpel ,  Sabrine Klaubauer ,  Christian Wagner ,  Andreas Fritz ,  Wilk Von Gustedt ,  Oliver Henrich ,  Dieter Maier ,  Fabio Spreafico ,  Ulrike Folkers ,  Sylvia Hopper ,  Wolfram Kemmner ,  Pamela Tan ,  Josephine Stiebler ,  Ricahrd Albang

发明人： Luppo Edens ,  Alard Van Albertus Dijk ,  Phillip Krubasik ,  Kaj Albermann ,  Alexander Stock ,  Erik Kimpel ,  Sabrine Klaubauer ,  Christian Wagner ,  Andreas Fritz ,  Wilk Von Gustedt ,  Oliver Henrich ,  Dieter Maier ,  Fabio Spreafico ,  Ulrike Folkers ,  Sylvia Hopper ,  Wolfram Kemmner ,  Pamela Tan ,  Josephine Stiebler ,  Ricahrd Albang

IPC分类号： C12N9/48 ,  C07H21/04 ,  C12N15/63 ,  C12N5/10 ,  C12P21/02

CPC分类号： C12Q1/37 ,  C07K2319/00 ,  C12N9/62 ,  G01N33/56961 ,  G01N33/573 ,  G01N2333/38

摘要： The invention relates to newly identified gene sequences that encode novel proteases obtainable from Aspergillus niger. The invention features the full length gene sequence of the novel genes, their cDNA sequences as well as the full-length functional protein and fragments thereof. The invention also relates to methods of using these enzymes in industrial processes and methods of diagnosing fungal infections. Also included in the invention are cells transformed with DNA according to the invention and cells wherein a protease according to the invention is genetically modified to enhance or reduce its activity and/or level of expression.

摘要翻译： 本发明涉及新鉴定的编码从黑曲霉获得的新型蛋白酶的基因序列。 本发明的特征在于新基因的全长基因序列，其cDNA序列以及全长功能蛋白及其片段。 本发明还涉及在工业过程中使用这些酶的方法和诊断真菌感染的方法。 本发明还包括用根据本发明的DNA转化的细胞和其中根据本发明的蛋白酶被遗传修饰以增强或降低其活性和/或表达水平的细胞。