公开(公告)号：US07301026B2

公开(公告)日：2007-11-27

申请号：US11410179

申请日：2006-04-24

申请人： Lushi Tan ,  Benjamin T. Dorner ,  Wenjie Li ,  Nobuyoshi Yasuda ,  Frederick W. Hartner

发明人： Lushi Tan ,  Benjamin T. Dorner ,  Wenjie Li ,  Nobuyoshi Yasuda ,  Frederick W. Hartner

IPC分类号： C07D221/18

CPC分类号： C07D471/04 ,  C07D221/18 ,  C07J73/005

摘要： The present invention relates to synthetic processes useful in the preparation of fluorinated 4-azasteroid derivatives that modulate androgen receptors and have application in the treatment of conditions caused by androgen deficiency or androgen receptor hyperactivity, such as osteoporosis, periodontal disease, bone fracture, frailty, erectile dysfunction, loss of libido, androgen-dependent cancers and sarcopenia. The present invention also encompasses intermediates useful in the disclosed synthetic processes and the methods of their preparation.

摘要翻译： 本发明涉及可用于制备调节雄激素受体并且用于治疗由雄激素缺乏或雄激素受体多动症引起的疾病的合成方法，例如骨质疏松症，牙周病，骨折，虚弱， 勃起功能障碍，性欲丧失，雄激素依赖性癌症和肌肉减少症。 本发明还包括在所公开的合成方法及其制备方法中有用的中间体。