公开(公告)号：US20250019696A1

公开(公告)日：2025-01-16

申请号：US18260789

申请日：2022-11-17

Applicant: MACAU UNIVERSITY OF SCIENCE AND TECHNOLOGY

Inventor： Zhihong JIANG ,  Yuan MA ,  Fei REN

IPC: C12N15/113 ,  A61K36/074 ,  A61P11/06

Abstract: A use of ganoderma fungal RNA molecules, a drug, a drug composition and a delivery carrier are provided. It has been proved that the tRFs derived from the ganoderma traditional Chinese medicine has an obvious inhibiting effect on airway smooth muscle cell phenotype change (proliferation, abnormal secretion and the like) induced by TGF-β1 and AHR, inflammation and remodeling of asthma mice induced by Dermatophagoides pteronyssinus in the experiments of the present disclosure, which suggests that the tRFs derived from the ganoderma traditional Chinese medicine and a pharmaceutical composition can be a brand new medicine for treating asthma. The drug comprises the RNA molecule and a pharmaceutically acceptable carrier, diluent and/or excipient. The present disclosure is helpful for the research and development of asthma treatment drugs and provides reference for the research and development of other respiratory system disease treatment drugs.